// Workers AI · dad joke modeWhat did SIGLEC7 say to SIGLEC8? "Let's cell-ebrate

SIGLEC7
Identifiers
Aliases	SIGLEC7, AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1, sialic acid binding Ig like lectin 7, AIRM-1
External IDs	OMIM: 604410; MGI: 1932475; HomoloGene: 130668; GeneCards: SIGLEC7; OMA:SIGLEC7 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NKO, 1O7S, 1O7V, 2DF3, 2G5R, 2HRL
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.41 Start 51,142,299 bp End 51,153,526 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 Start 43,300,494 bp End 43,309,585 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen gonad testicle appendix amniotic fluid lymph node right adrenal cortex Top expressed in granulocyte zygote secondary oocyte spleen blood embryo embryo right kidney bone marrow primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell adhesion regulation of immune response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27036 83382 Ensembl ENSG00000168995 ENSMUSG00000030474 UniProt Q9Y286 Q91Y57 RefSeq (mRNA) NM_001277201 NM_014385 NM_016543 NM_031181 RefSeq (protein) NP_001264130 NP_055200 NP_057627 NP_112458 Location (UCSC) Chr 19: 51.14 – 51.15 Mb Chr 7: 43.3 – 43.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).

Further reading

• Reif K, Buday L, Downward J, Cantrell DA (1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases". J. Biol. Chem. 269 (19): 14081–7. doi:10.1016/S0021-9258(17)36757-1. PMID 8188688.
• Falco M, Biassoni R, Bottino C, et al. (1999). "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells". J. Exp. Med. 190 (6): 793–802. doi:10.1084/jem.190.6.793. PMC 2195632. PMID 10499918.
• Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
• Vitale C, Romagnani C, Falco M, et al. (2000). "Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15091–6. doi:10.1073/pnas.96.26.15091. PMC 24778. PMID 10611343.
• Angata T, Varki A (2000). "Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily". Glycobiology. 10 (4): 431–8. doi:10.1093/glycob/10.4.431. PMID 10764831.
• Ito A, Handa K, Withers DA, et al. (2001). "Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression". FEBS Lett. 498 (1): 116–20. Bibcode:2001FEBSL.498..116I. doi:10.1016/S0014-5793(01)02476-0. PMID 11389909. S2CID 6755832.
• Mingari MC, Vitale C, Romagnani C, et al. (2001). "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors". Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology. Vol. 495. pp. 55–61. doi:10.1007/978-1-4615-0685-0_8. ISBN 978-1-4613-5194-8. PMID 11774609.
• Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene. 286 (2): 259–70. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481.
• Alphey MS, Attrill H, Crocker PR, van Aalten DM (2003). "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family". J. Biol. Chem. 278 (5): 3372–7. doi:10.1074/jbc.M210602200. PMID 12438315.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nicoll G, Avril T, Lock K, et al. (2003). "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms". Eur. J. Immunol. 33 (6): 1642–8. doi:10.1002/eji.200323693. PMID 12778482. S2CID 7541832.
• Dimasi N, Moretta A, Moretta L, et al. (2004). "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1". Acta Crystallogr. D. 60 (Pt 2): 401–3. doi:10.1107/S0907444903028439. PMID 14747738.
• Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9". J. Biol. Chem. 279 (41): 43117–25. doi:10.1074/jbc.M403538200. PMID 15292262.
• Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells". J. Immunol. 173 (11): 6841–9. doi:10.4049/jimmunol.173.11.6841. PMID 15557178.
• Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y (2005). "Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs". Glycobiology. 15 (7): 667–76. doi:10.1093/glycob/cwi048. PMID 15703304.
• Attrill H, Takazawa H, Witt S, et al. (2006). "The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design". Biochem. J. 397 (2): 271–8. doi:10.1042/BJ20060103. PMC 1513286. PMID 16623661.
• Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727. S2CID 11537303.
• Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.

External links

• SIGLEC7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.