IL18RAP

IL18RAP
Identifiers
Aliases	IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDs	OMIM: 604509; MGI: 1338888; HomoloGene: 2859; GeneCards: IL18RAP; OMA:IL18RAP - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WO4
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,452,565 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,590,865 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; bone marrow; ; spleen; ; trabecular bone; ; right lung; ; bone marrow cell; ; upper lobe of left lung; ; periodontal fiber; ; appendix;
	Top expressed in
	granulocyte; ; blood; ; tibiofemoral joint; ; embryo; ; bone marrow; ; spleen; ; zygote; ; endothelial cell of lymphatic vessel; ; carotid body; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity; interleukin-18 receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; interleukin-18 receptor complex;
Biological process	cell surface receptor signaling pathway; inflammatory response; immune response; cellular response to cytokine stimulus; signal transduction; cellular response to hydrogen peroxide; cell population proliferation; interleukin-6 production; T-helper 1 cell cytokine production; neutrophil activation; positive regulation of natural killer cell mediated cytotoxicity; cellular response to interleukin-18; interleukin-18-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	8807
	16174
	ENSG00000115607
	ENSMUSG00000026068
	O95256
	Q9Z2B1
	NM_003853
	NM_010553
	NP_003844
	NP_034683
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.^[5]^[6]

Function

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.^[5]

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115607 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026068 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".
↑ Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.
↑ Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMC 2673512. PMID 18311140.

External links

IL18RAP+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115607 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026068 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_8807-5] 1 2 "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".

[pmid9792649-6] Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.

[pmid18311140-7] Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMC 2673512. PMID 18311140.

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[2]

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[5]

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351–371	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371
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IL18RAP

Function

Disease association

See also

References

Further reading

External links