RhoGAP domain

Available protein structures:
PDB	‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1xa6A:291-444 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1f7cA:199-355 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1am4B:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1grnB:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1ow3A:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1rgp :260-402 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1tx4A:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 2ngrB:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1pbwB:129-281 IPR000198 PF00620 (ECOD; PDBsum)
AlphaFold	IPR000198; PF00620;

RhoGAP domain
RhoGAP domain
	Structure of Phospholipase A2.
Identifiers
Symbol	RhoGAP
Pfam	PF00620
InterPro	IPR000198
SMART	RhoGAP
PROSITE	PDOC50238
SCOP2	1rgb / SCOPe / SUPFAM
OPM protein	1xa6
CDD	cd00159
PDB
Available protein structures:
PDB	‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1xa6A:291-444 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1f7cA:199-355 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1am4B:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1grnB:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1ow3A:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1rgp :260-402 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1tx4A:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 2ngrB:260-408 ‹ The template below (Protein Data Bank link 3) is being considered for merging with PDBsum link. See templates for discussion to help reach a consensus. › 1pbwB:129-281 IPR000198 PF00620 (ECOD; PDBsum)
AlphaFold	IPR000198; PF00620;

RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.

Human proteins containing this domain

ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6; ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1; CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1; FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158; MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3; STARD13; STARD8; SYDE1; SYDE2;

Notes

↑ Georgieva DN, Rypniewski W, Gabdoulkhakov A, Genov N, Betzel C (July 2004). "Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition". Biochem. Biophys. Res. Commun. 319 (4): 1314–21. doi:10.1016/j.bbrc.2004.05.106. PMID 15194511.

References

Musacchio, A.; Cantley, L. C.; Harrison, S. C. (1996). "Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14373–14378. doi:10.1073/pnas.93.25.14373. PMC 26139. PMID 8962058.
Barrett, T.; Xiao, B.; Dodson, E. J.; Dodson, G.; Ludbrook, S. B.; Nurmahomed, K.; Gamblin, S. J.; Musacchio, A.; Smerdon, S. J.; Eccleston, J. F. (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615): 458–461. doi:10.1038/385458a0. PMID 9009196. S2CID 4235645.
Gamblin, S. J.; Rittinger, K.; Walker, P. A.; Eccleston, J. F.; Nurmahomed, K.; Owen, D.; Laue, E.; Smerdon, S. J. (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643): 693–697. doi:10.1038/41805. PMID 9262406. S2CID 4415826.
Boguski, M. S.; McCormick, F. (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643–654. doi:10.1038/366643a0. PMID 8259209. S2CID 4338237.

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[pmid15194511-1] Georgieva DN, Rypniewski W, Gabdoulkhakov A, Genov N, Betzel C (July 2004). "Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition". Biochem. Biophys. Res. Commun. 319 (4): 1314–21. doi:10.1016/j.bbrc.2004.05.106. PMID 15194511.

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RhoGAP domain

Human proteins containing this domain

Notes

References