// Workers AI · dad joke modeDoes ARHGAP4 have gaps? Yes, it's a 4-getful gene.

ARHGAP4
Identifiers
Aliases	ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	OMIM: 300023; MGI: 2159577; GeneCards: ARHGAP4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EPD
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 153,907,367 bp End 153,934,999 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 72,935,048 bp End 72,965,476 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte lymph node blood right lung upper lobe of left lung appendix right hemisphere of cerebellum apex of heart Top expressed in granulocyte thymus spleen mesenteric lymph nodes blood tibiofemoral joint bone marrow subcutaneous adipose tissue otic vesicle embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity identical protein binding Cellular component cytosol Golgi apparatus growth cone microtubule cytoplasm Biological process negative regulation of fibroblast migration nervous system development positive regulation of GTPase activity negative regulation of cell migration cytoskeleton organization Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of axon extension signal transduction positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 393 171207 Ensembl ENSG00000089820 ENSMUSG00000031389 UniProt P98171 n/a RefSeq (mRNA) NM_001666 NM_001164741 NM_001162423 NM_001162424 NM_138630 RefSeq (protein) NP_001158213 NP_001657 n/a Location (UCSC) Chr X: 153.91 – 153.93 Mb Chr X: 72.94 – 72.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth in vitro.

External links

• Human ARHGAP4 genome location and ARHGAP4 gene details page in the UCSC Genome Browser.

Further reading

• Tribioli C, Mancini M, Plassart E, Bione S, Rivella S, Sala C, et al. (July 1994). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Human Molecular Genetics. 3 (7): 1061–1067. doi:10.1093/hmg/3.7.1061. PMID 7981673.
• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Zuber J, Tchernitsa OI, Hinzmann B, Schmitz AC, Grips M, Hellriegel M, et al. (February 2000). "A genome-wide survey of RAS transformation targets". Nature Genetics. 24 (2): 144–152. doi:10.1038/72799. PMID 10655059. S2CID 21887748.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Demura M, Takeda Y, Yoneda T, Furukawa K, Usukura M, Itoh Y, et al. (January 2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus". Human Mutation. 19 (1): 23–29. doi:10.1002/humu.10011. PMID 11754100. S2CID 21379792.
• Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, et al. (August 2002). "p115 Rho GTPase activating protein interacts with MEKK1". Journal of Cellular Physiology. 192 (2): 200–208. doi:10.1002/jcp.10125. PMID 12115726. S2CID 33717402.
• Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules". Brain Research. Molecular Brain Research. 107 (1): 65–79. doi:10.1016/S0169-328X(02)00448-5. PMID 12414125.
• Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, et al. (December 2002). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nature Cell Biology. 4 (12): 970–975. doi:10.1038/ncb886. PMID 12447388. S2CID 1423222.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". International Journal of Molecular Medicine. 11 (6): 791–797. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.