ARHGAP18

ARHGAP18
Identifiers
Aliases	ARHGAP18, MacGAP, SENEX, bA307O14.2, Rho GTPase activating protein 18
External IDs	OMIM: 613351; MGI: 1921160; GeneCards: ARHGAP18
Gene location (Human)
Chr.	Chromosome 6 (human)
End	129,710,177 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	26,794,644 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; bronchial epithelial cell; ; oocyte; ; secondary oocyte; ; parietal pleura; ; visceral pleura; ; pancreatic epithelial cell; ; mucosa of paranasal sinus; ; renal medulla; ; jejunal mucosa;
	Top expressed in
	cumulus cell; ; left lung lobe; ; blood; ; epithelium of small intestine; ; dermis; ; migratory enteric neural crest cell; ; seminal vesicula; ; right kidney; ; epithelium of stomach; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; cadherin binding;
Cellular component	cytoplasm; cytosol; plasma membrane; nuclear speck;
Biological process	regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; regulation of actin cytoskeleton organization; signal transduction; regulation of cell shape; regulation of cell motility; positive regulation of GTPase activity; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	93663
	73910
	ENSG00000146376
	ENSMUSG00000039031
	Q8N392
	Q8K0Q5
	NM_033515
	NM_176837
	NP_277050
	NP_789807
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase activating protein 18 is a protein that in humans is encoded by the ARHGAP18 gene.^[5] The gene is also known as MacGAP and bA307O14.2.^[5] ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146376 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039031 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Rho GTPase activating protein 18". Retrieved 2011-12-05.
↑ Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, et al. (April 2009). "Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia". Molecular Psychiatry. 14 (4): 416–428. doi:10.1038/mp.2008.127. PMC 3254586. PMID 19065146.

Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (February 2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". European Journal of Human Genetics. 17 (2): 213–218. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, et al. (July 2006). "Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags". Biochemical and Biophysical Research Communications. 345 (3): 1022–1032. Bibcode:2006BBRC..345.1022W. doi:10.1016/j.bbrc.2006.04.175. PMID 16712791.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146376 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Rho GTPase activating protein 18". Retrieved 2011-12-05.

[6] Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, et al. (April 2009). "Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia". Molecular Psychiatry. 14 (4): 416–428. doi:10.1038/mp.2008.127. PMC 3254586. PMID 19065146.

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ARHGAP18

References

Further reading