MST1

For mammalian sterile 20–like kinase-1, see STK4.

Not to be confused with Macrophage colony-stimulating factor.

MST1
Identifiers
Aliases	MST1, D3F15S2, DNF15S2, HGFL, MSP, NF15S2, macrophage stimulating 1
External IDs	OMIM: 142408; MGI: 96080; HomoloGene: 7360; GeneCards: MST1; OMA:MST1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ASU, 4QT8
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,683,947 bp End 49,689,501 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 59.07 cM Start 107,957,635 bp End 107,962,202 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum left testis left lobe of thyroid gland right testis right lobe of thyroid gland human kidney right uterine tube pituitary gland left adrenal cortex Top expressed in left lobe of liver liver parenchyma fetal liver hematopoietic progenitor cell ankle joint embryo transitional epithelium of urinary bladder embryo esophagus lip corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding protein binding serine-type endopeptidase activity Cellular component extracellular region extracellular space collagen-containing extracellular matrix Biological process proteolysis regulation of cAMP-dependent protein kinase activity hepatocyte growth factor receptor signaling pathway negative regulation of gluconeogenesis regulation of macrophage chemotaxis positive regulation of mammary gland epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4485 15235 Ensembl ENSG00000173531 ENSMUSG00000032591 UniProt P26927 P26928 RefSeq (mRNA) NM_020998 NM_001393581 NM_001393582 NM_001393583 NM_001393584 NM_001393585 NM_008243 RefSeq (protein) NP_066278 NP_032269 Location (UCSC) Chr 3: 49.68 – 49.69 Mb Chr 9: 107.96 – 107.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.

Further reading

• Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40): 9768–80. doi:10.1021/bi00104a029. PMID 1655021.
• Skeel A, Yoshimura T, Showalter SD, et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity". J. Exp. Med. 173 (5): 1227–34. doi:10.1084/jem.173.5.1227. PMC 2118857. PMID 1827141.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J. Biol. Chem. 271 (15): 9024–32. doi:10.1074/jbc.271.15.9024. PMID 8621550.
• Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain". J. Biol. Chem. 271 (35): 21049–53. doi:10.1074/jbc.271.35.21049. PMID 8702870.
• Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yoshikawa W, Hara H, Takehara T, et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein". Arch. Biochem. Biophys. 363 (2): 356–60. doi:10.1006/abbi.1998.1090. PMID 10068459.
• Degen SJ, McDowell SA, Waltz SE, et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq. 8 (6): 409–13. doi:10.3109/10425179809020903. PMID 10728827.
• Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein". J. Biol. Chem. 276 (24): 21932–7. doi:10.1074/jbc.M100652200. PMID 11274154.
• Rampino T, Collesi C, Gregorini M, et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells". J. Am. Soc. Nephrol. 13 (3): 649–57. doi:10.1681/ASN.V133649. PMID 11856768.
• Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages". J. Biol. Chem. 277 (41): 38104–10. doi:10.1074/jbc.M206167200. PMID 12177064.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
• Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
• Matsuzaki S, Canis M, Pouly JL, et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis". Mol. Hum. Reprod. 11 (5): 345–9. doi:10.1093/molehr/gah162. PMID 15764806.
• Zalcenstein A, Weisz L, Stambolsky P, et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53". Oncogene. 25 (3): 359–69. doi:10.1038/sj.onc.1209061. PMID 16170349.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.