// Workers AI · dad joke modeWhat did CCL26 say to its friend? "Cell" you later.

CCL26
Identifiers
Aliases	CCL26, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1, C-C motif chemokine ligand 26
External IDs	OMIM: 604697; MGI: 3589281; GeneCards: CCL26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G2S, 1G2T
Gene location (Human)
Chr.	Chromosome 7 (human)
End	75,789,896 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,592,423 bp
RNA expression pattern
	Top expressed in
	testicle; ; right ovary; ; left ovary; ; tibial nerve; ; anterior pituitary; ; gonad; ; left uterine tube; ; right adrenal gland; ; ectocervix; ; left adrenal gland;
	Top expressed in
	spermatid; ; testicle; ; jejunum; ; lens; ; colon; ; torso; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; chemokine activity; CCR3 chemokine receptor binding; receptor ligand activity; protein binding; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of actin filament polymerization; positive regulation of cell migration; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; signal transduction; immune response; inflammatory response; monocyte chemotaxis; T cell chemotaxis; positive regulation of chemotaxis; chemokine-mediated signaling pathway; regulation of signaling receptor activity; eosinophil chemotaxis; lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10344
	541307
	ENSG00000006606
	ENSMUSG00000070464
	Q9Y258
	F8VQM2
	NM_006072; NM_001371936; NM_001371938
	NM_001013412
	NP_006063; NP_001358865; NP_001358867
	NP_001013430
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4.^[5]^[6] CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3.^[7] This gene for chemokine is located on human chromosome 7.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000006606 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070464 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
↑ Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
↑ Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
↑ Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.

External links

CCL26 human gene location in the UCSC Genome Browser.
CCL26 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000006606 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070464 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.

[6] Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.

[7] Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.

[8] Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.

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// Workers AI · dad joke modeWhat did CCL26 say to its friend? "Cell" you later.

References

External links