IFNA6

IFNA6
Identifiers
Aliases	IFNA6, IFN-alphaK, interferon alpha 6
External IDs	OMIM: 147566; MGI: 2667155; HomoloGene: 105727; GeneCards: IFNA6; OMA:IFNA6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 21,349,835 bp End 21,351,378 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 42.02 cM Start 88,561,878 bp End 88,562,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus Brodmann area 9 amygdala substantia nigra hippocampus proper occipital lobe primary visual cortex nucleus accumbens hypothalamus Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space cellular component Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3443 230396 Ensembl ENSG00000120235 ENSMUSG00000063376 UniProt P05013 Q80SU4 RefSeq (mRNA) NM_021002 NM_177347 RefSeq (protein) NP_066282 NP_796321 Location (UCSC) Chr 9: 21.35 – 21.35 Mb Chr 4: 88.56 – 88.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.