MAST1

MAST1
Identifiers
Aliases	MAST1, SAST, SAST170, microtubule associated serine/threonine kinase 1, MCCCHCM
External IDs	OMIM: 612256; MGI: 1861901; HomoloGene: 10543; GeneCards: MAST1; OMA:MAST1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M9X, 3PS4
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,833,951 bp End 12,874,952 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C3|8 41.32 cM Start 85,638,532 bp End 85,663,988 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe ganglionic eminence anterior cingulate cortex Brodmann area 9 paraflocculus of cerebellum prefrontal cortex frontal pole Brodmann area 10 anterior pituitary Top expressed in motor neuron cerebellar cortex central gray substance of midbrain superior colliculus pontine nuclei ventromedial nucleus primary visual cortex dorsomedial hypothalamic nucleus dorsal tegmental nucleus cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding metal ion binding kinase activity Cellular component cytoplasm plasma membrane intracellular anatomical structure cytoskeleton membrane Biological process protein phosphorylation intracellular signal transduction cytoskeleton organization peptidyl-serine phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22983 56527 Ensembl ENSG00000105613 ENSMUSG00000053693 UniProt Q9Y2H9 Q9R1L5 RefSeq (mRNA) NM_014975 NM_019945 RefSeq (protein) NP_055790 NP_064329 Location (UCSC) Chr 19: 12.83 – 12.87 Mb Chr 8: 85.64 – 85.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Yano R, Yap CC, Yamazaki Y, et al. (2003). "Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions". Neuroscience. 117 (2): 373–81. doi:10.1016/S0306-4522(02)00785-6. PMID 12614677. S2CID 125224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
• Lumeng C, Phelps S, Crawford GE, et al. (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183. S2CID 20910888.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.