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Amitriptyline/chlordiazepoxide

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From Wikipedia, the free encyclopedia
(Redirected from Limbitrol)

Amitriptyline/chlordiazepoxide
Amitriptyline (top) and chlordiazepoxide (bottom)
Combination of
AmitriptylineTricyclic antidepressant
ChlordiazepoxideBenzodiazepine
Clinical data
Pronunciation/ˌklɔːr.daɪəz.ɪˈpɒksaɪd/ /ˌæmɪˈtrɪptɪliːn/[1]
Trade namesLimbitrol, Limbitrol DS
Routes of
administration		Oral
Legal status
Legal status
  • In general: ℞ (Prescription only)

Amitriptyline/chlordiazepoxide, sold under the brand names Limbitrol and Limbitrol DS, is a combination of amitriptyline (Elavil), a tricyclic antidepressant, and chlordiazepoxide (Librium), a benzodiazepine, which is approved for the treatment of depression associated with anxiety in the United States.[2][3] It is taken orally and contains 12.5 to 25 mg amitriptyline and 5 to 10 mg chlordiazepoxide per tablet.[1][2][3]

Medical uses

[edit]

Amitriptyline/chlordiazepoxide is used for the treatment of moderate to severe depression associated with moderate to severe anxiety.[1][3] It has shown to be more effective in treating symptoms of anxiety, irritability, and hostility in patients with comorbid depression and anxiety than amitriptyline alone.[4]: 174  It also has a quicker onset time than either amitriptyline or chlordiazepoxide on their own.[1][4]: 174 

Contraindications and precautions

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Amitriptyline/chlordiazepoxide should not be taken if the patient has recently had a heart attack.[1][5] It may induce a mixed-manic episode in patients with a history of bipolar disorder or who have had manic or hypomanic episodes in the past.[1] Amitriptyline/chlordiazepoxide may worsen seizures in patients with a previous history of them.[1][5] Patients older than 65 years of age may be more sensitive to amitriptyline/chlordiazepoxide.[6] It may also have stronger effects on patients with kidney or liver disease due to slowed filtering from the bloodstream.[1][5] It may also cause adverse effects in patients with a thyroid condition such as hyperthyroidism.[1][5][6] Use of amitriptyline/chlordiazepoxide later in pregnancy can cause sedation or symptoms of withdrawl in the infant after delivery.[1][5][6] The safety of amitriptyline/chlordiazepoxide for breastfeeding or pediatric patients is unknown.[5]

Drug interactions

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Amitriptyline/chlordiazepoxide should not be taken concomitantly with MAOIs, as doing so may cause high blood pressure and seizures .[1][5] Like other benzodiazepines, concomitant use of amitriptyline/chlordiazepoxide with opioids increases the risk of drug-related mortality by way of profound sedation and respiratory depression.[1]

Side effects

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The most common side effects of amitriptyline/chlordiazepoxide are dry mouth, bloating, dizziness, and constipation.[1][5][6][4]: 173  It may also cause blurred vision or increased depression.[1][5][6] Amitriptyline/chlordiazepoxide can also cause serotonin syndrome.[1][5][6]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 "DailyMed - CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE tablet, film coated". dailymed.nlm.nih.gov. National Institutes of Health. Retrieved 31 August 2026.
  2. 1 2 Mylan Pharmaceuticals Inc. (May 2014). "Chlordiazepoxide and Amitriptyline Tablets Label" (PDF). U.S. Food and Drug Administration. Archived from the original (PDF) on February 10, 2017.
  3. 1 2 3 Townsend MC, Morgan KI (9 January 2018). Pocket Guide to Psychiatric Nursing. F.A. Davis. pp. 443–. ISBN 978-0-8036-7705-0. OCLC 1019871725.
  4. 1 2 3 Smith M (1973). "Clinical response to amitriptyline and chlordiazepoxide-amitriptyline (Limbitrol) in anxiety-depressive states. A double-blind study". Psychosomatics. 14 (3): 168–175. doi:10.1016/S0033-3182(73)71352-9. PMID 4604233.
  5. 1 2 3 4 5 6 7 8 9 10 "Chlordiazepoxide and amitriptyline (oral route)". mayoclinic.org. Mayo Foundation for Medical Education and Research.
  6. 1 2 3 4 5 6 "Chlordiazepoxide; Amitriptyline Tablets". clevelandclinic.org. Cleveland Clinic. 2023-09-20. Retrieved 1 September 2026.
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