// Workers AI · dad joke modeWhat did IHCH-8110 say to its friend? "I'm a byte ahead.

IHCH-8110

Clinical data
Other names	IHCH8110
Drug class	Peripherally selective and non-hallucinogenic serotonin 5-HT2A receptor agonist; Serotonin 5-HT2B receptor antagonist; Serotonin 5-HT2C receptor agonist
ATC code	None
Identifiers
IUPAC name N-methyl-N-(trans-4-aminocyclohexyl)-N'-(4-n-hexyloxybenzyl)urea
Chemical and physical data
Formula	C21H35N3O2
Molar mass	361.530 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCOC1=CC=C(CNC(N([C@@H]2CC[C@@H](N)CC2)C)=O)C=C1
InChI InChI=1S/C21H35N3O2/c1-3-4-5-6-15-26-20-13-7-17(8-14-20)16-23-21(25)24(2)19-11-9-18(22)10-12-19/h7-8,13-14,18-19H,3-6,9-12,15-16,22H2,1-2H3,(H,23,25)/t18-,19- Key:BZQLUNPSADKUSQ-WGSAOQKQSA-N

IHCH-8110 is a peripherally selective and non-hallucinogenic serotonin 5-HT_2A receptor agonist.

Pharmacology

IHCH-8110 shows affinity for the serotonin 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors (K_i = 48 nM, 102 nM, and 302 nM, respectively). The drug is a partial agonist at the serotonin 5-HT_2A receptor with an EC₅₀Tooltip half-maximal effective concentration of 93–479 nM and E_maxTooltip maximal efficacy of 45–68%. It is also a partial agonist of the serotonin 5-HT_2C receptor but not of the serotonin 5-HT_2B receptor, where it instead functioned as an antagonist. The drug did not interact with other serotonin or dopamine receptors.

IHCH-8110 is highly peripherally selective and does not produce the head-twitch response, a behavioral proxy of psychedelic effects, nor affect locomotor activity in rodents. It has been found to enhance CD8⁺ T cell-mediated antitumor immunity and inflammation and to suppress colorectal cancer progression, effects mediated by activation of serotonin 5-HT_2A receptors on enteric glial cells that results in increased CXCL10 and interleukin-18 expression.

Chemistry

The chemical synthesis of IHCH-8110 has been described.

History

IHCH-8110 was first described in the scientific literature by YaTing Wen and colleagues in 2026. It was developed following observations of the psychedelic drug LSD having similar colonic effects. There is interest in IHCH-8110 for potential medical use in colorectal cancer immunotherapy.

See also

• Serotonin 5-HT_2A receptor agonist
• List of miscellaneous 5-HT_2A receptor agonists