Interleukin 1 receptor, type II

IL1R2
Identifiers
Aliases	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDs	OMIM: 147811; MGI: 96546; HomoloGene: 7783; GeneCards: IL1R2; OMA:IL1R2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O4O
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,028,544 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,164,391 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; mucosa of sigmoid colon; ; decidua; ; mucosa of pharynx; ; blood; ; right lung; ; epithelium of nasopharynx; ; human penis; ; oral cavity; ; vulva;
	Top expressed in
	gastrula; ; granulocyte; ; skin of external ear; ; decidua; ; esophagus; ; lip; ; skin of back; ; subcutaneous adipose tissue; ; primary oocyte; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type II, blocking receptor activity; protein binding; interleukin-1 receptor activity; interleukin-1 binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; membrane; cytoplasm;
Biological process	immune response; negative regulation of protein processing; negative regulation of cytokine production involved in inflammatory response; negative regulation of interleukin-1-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7850
	16178
	ENSG00000115590
	ENSMUSG00000026073
	P27930
	P27931
	NM_001261419; NM_004633; NM_173343
	NM_010555; NM_001360800; NM_001360801
	NP_001248348; NP_004624
	NP_034685; NP_001347729; NP_001347730
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

Function

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,^[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.^[6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115590 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026073 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, et al. (December 1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
↑ Wang D, Zhang S, Li L, Liu X, Mei K, Wang X (October 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.
↑ "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, et al. (October 1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821–2832. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP (October 1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry. 266 (30): 20311–20315. doi:10.1016/S0021-9258(18)54924-3. PMID 1834644.
Fasano MB, Cousart S, Neal S, McCall CE (November 1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation. 88 (5): 1452–1459. doi:10.1172/JCI115454. PMC 295647. PMID 1834697.
Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J (September 1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation; A Journal of Technical Methods and Pathology. 73 (3): 347–355. PMID 7564267.
Symons JA, Young PR, Duff GW (February 1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1714–1718. Bibcode:1995PNAS...92.1714S. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046.
Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, et al. (November 1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology. 153 (10): 4766–4774. doi:10.4049/jimmunol.153.10.4766. PMID 7963543. S2CID 23226920.
Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, et al. (December 1994). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802–5809. doi:10.4049/jimmunol.153.12.5802. PMID 7989776. S2CID 20750506.
Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, Mantovani A, et al. (February 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine. 179 (2): 739–743. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881.
Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, et al. (July 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–475. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
Sambo P, Fadlon EJ, Sironi M, Matteucci C, Introna M, Mantovani A, et al. (March 1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood. 87 (5): 1682–1686. doi:10.1182/blood.V87.5.1682.bloodjournal8751682. PMID 8634411.
Larregina A, Morelli A, Kolkowski E, Fainboim L (February 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology. 87 (2): 317–325. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397.
Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, De Souza EB (August 1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry. 271 (34): 20965–20972. doi:10.1074/jbc.271.34.20965. PMID 8702856.
Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M, et al. (April 1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology. 156 (7): 2534–2541. doi:10.4049/jimmunol.156.7.2534. PMID 8786316. S2CID 7669945.
Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (August 1996). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636–641. doi:10.1006/cyto.1996.0085. PMID 8894439.
Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, et al. (November 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–122. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (January 1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases. 175 (1): 118–122. doi:10.1093/infdis/175.1.118. PMID 8985204.
Rauschmayr T, Groves RW, Kupper TS (May 1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America. 94 (11): 5814–5819. Bibcode:1997PNAS...94.5814R. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157.
Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, et al. (June 1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513–1526. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
Cannon JG, Angel JB, Abad LW, Vannier E, Mileno MD, Fagioli L, et al. (May 1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology. 17 (3): 253–261. doi:10.1023/A:1027314713231. PMID 9168406. S2CID 13013291.
Fink GW, Norman JG (December 1997). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine. 9 (12): 1023–1027. doi:10.1006/cyto.1997.0260. PMID 9417814.

External links

IL1R2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115590 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026073 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, et al. (December 1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.

[6] Wang D, Zhang S, Li L, Liu X, Mei K, Wang X (October 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.

[entrez-7] "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351–371	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371
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Interleukin 1 receptor, type II

Function

See also

References

Further reading

External links