// Workers AI · dad joke modeWhat did ANAPC1 say to its friend? "Cell" me maybe.

ANAPC1
Identifiers
Aliases	ANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDs	OMIM: 608473; MGI: 103097; GeneCards: ANAPC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G04, 5G05
Gene location (Human)
Chr.	Chromosome 2 (human)
End	111,884,690 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	128,529,311 bp
RNA expression pattern
	Top expressed in
	gonad; ; epithelium of colon; ; pancreatic ductal cell; ; Achilles tendon; ; testicle; ; tibialis anterior muscle; ; endothelial cell; ; bone marrow cell; ; deltoid muscle; ; ventricular zone;
	Top expressed in
	Gonadal ridge; ; tail of embryo; ; somite; ; genital tubercle; ; mandibular prominence; ; epiblast; ; endothelial cell of lymphatic vessel; ; primitive streak; ; maxillary prominence; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity;
Cellular component	nucleoplasm; cytosol; anaphase-promoting complex; nucleus;
Biological process	cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; metaphase; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64682
	17222
	ENSG00000153107
	ENSMUSG00000014355
	Q9H1A4
	P53995
	NM_022662
	NM_008569
	NP_073153
	NP_032595
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.^[5]^[6]

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).^[6]

Interactions

ANAPC1 has been shown to interact with ANAPC5,^[7]^[8] ANAPC4,^[7]^[8] ANAPC2,^[7]^[8] CDC27^[7]^[8] and ANAPC7.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153107 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014355 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–59. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
1 2 "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
1 2 3 4 5 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
1 2 3 4 5 Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

External links

Human ANAPC1 genome location and ANAPC1 gene details page in the UCSC Genome Browser.

Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–14507. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (September 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11317–11322. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
Zur A, Brandeis M (2001). "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis". The EMBO Journal. 20 (4): 792–801. doi:10.1093/emboj/20.4.792. PMC 145417. PMID 11179223.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. (December 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal. 22 (24): 6598–6609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153107 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Jorgensen_2001-5] Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–59. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.

[entrez-6] 1 2 "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".

[Vodermaier_2003-7] 1 2 3 4 5 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.

[Sumara_2000-8] 1 2 3 4 5 Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

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// Workers AI · dad joke modeWhat did ANAPC1 say to its friend? "Cell" me maybe.

Interactions

References

External links

Further reading