ANAPC4

ANAPC4
Identifiers
Aliases	ANAPC4, APC4, anaphase promoting complex subunit 4
External IDs	OMIM: 606947; MGI: 1098673; GeneCards: ANAPC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5BPW, 5A31, 5G05, 5G04
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,418,498 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,025,139 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; endometrium; ; tendon of biceps brachii; ; germinal epithelium; ; bronchial epithelial cell; ; parietal pleura; ; visceral pleura; ; Brodmann area 23; ; thymus; ; tibia;
	Top expressed in
	primary oocyte; ; neural layer of retina; ; superior cervical ganglion; ; ventricular zone; ; pituitary gland; ; vas deferens; ; ganglionic eminence; ; limb bud; ; fossa; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein phosphatase binding; protein binding; ubiquitin protein ligase activity;
Cellular component	anaphase-promoting complex; cytosol; nucleus; nucleoplasm; nuclear periphery;
Biological process	anaphase-promoting complex-dependent catabolic process; regulation of mitotic metaphase/anaphase transition; cell division; protein K11-linked ubiquitination; cell cycle; protein ubiquitination; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29945
	52206
	ENSG00000053900
	ENSMUSG00000029176
	Q9UJX5
	Q91W96
	NM_001286756; NM_013367
	NM_024213
	NP_001273685; NP_037499
	NP_077175
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.^[5]^[6]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.^[6]

Interactions

ANAPC4 has been shown to interact with ANAPC1,^[7]^[8] ANAPC5,^[7] CDC27^[7]^[9] and ANAPC7.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000053900 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029176 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". Journal of Immunology. 129 (4). Baltimore: 1474–1478. doi:10.4049/jimmunol.129.4.1474. PMID 6180011.
1 2 "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".
1 2 3 4 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

External links

Human ANAPC4 genome location and ANAPC4 gene details page in the UCSC Genome Browser.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (February 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354). New York, N.Y.: 1219–1222. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–14507. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (September 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11317–11322. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. (December 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal. 22 (24): 6598–6609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. (December 2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653). New York, N.Y.: 2141–2144. Bibcode:2003Sci...302.2141J. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000053900 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029176 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Tekolf_1982-5] Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". Journal of Immunology. 129 (4). Baltimore: 1474–1478. doi:10.4049/jimmunol.129.4.1474. PMID 6180011.

[entrez-6] 1 2 "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".

[Vodermaier_2003-7] 1 2 3 4 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.

[Sumara_2000-8] Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

[Gmachl_2000-9] Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

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ANAPC4

Interactions

References

External links

Further reading