ANAPC2

ANAPC2
Identifiers
Aliases	ANAPC2, APC2, anaphase promoting complex subunit 2
External IDs	OMIM: 606946; MGI: 2139135; GeneCards: ANAPC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 4YII, 5A31, 5G05, 5G04
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,188,560 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,175,927 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; left testis; ; right testis; ; granulocyte; ; left ovary; ; right ovary; ; skin of leg; ; tibial nerve; ; skin of abdomen;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; ventricular zone; ; dermis; ; calvaria; ; vestibular membrane of cochlear duct; ; utricle; ; neural tube; ; efferent ductule; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; ubiquitin protein ligase binding; protein binding;
Cellular component	cytosol; nucleoplasm; anaphase-promoting complex; nucleus;
Biological process	cell differentiation; ubiquitin-dependent protein catabolic process; nervous system development; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; cell division; positive regulation of synapse maturation; positive regulation of dendrite morphogenesis; protein ubiquitination; cell cycle; anaphase-promoting complex-dependent catabolic process; positive regulation of axon extension; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29882
	99152
	ENSG00000176248
	ENSMUSG00000026965
	Q9UJX6
	Q8BZQ7
	NM_013366
	NM_175300
	NP_037498
	NP_780509
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.^[5]^[6]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.^[6]

Interactions

ANAPC2 has been shown to interact with ANAPC1^[7]^[8] and ANAPC11.^[5]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176248 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026965 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, et al. (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Molecular Biology of the Cell. 12 (12): 3839–3851. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
1 2 "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
↑ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Molecular Cell. 3 (4): 535–541. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407. S2CID 19371828.

External links

Human ANAPC2 genome location and ANAPC2 gene details page in the UCSC Genome Browser.
Human APC2 genome location and APC2 gene details page in the UCSC Genome Browser.

Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (February 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354). New York, N.Y.: 1219–1222. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–14507. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (September 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11317–11322. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
Jarrett CR, Blancato J, Cao T, Bressette DS, Cepeda M, Young PE, et al. (November 2001). "Human APC2 localization and allelic imbalance". Cancer Research. 61 (21): 7978–7984. PMID 11691822.
Capron A, Serralbo O, Fülöp K, Frugier F, Parmentier Y, Dong A, et al. (October 2003). "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit". The Plant Cell. 15 (10): 2370–2382. doi:10.1105/tpc.013847. PMC 197302. PMID 14508008.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. (December 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal. 22 (24): 6598–6609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Dube P, Herzog F, Gieffers C, Sander B, Riedel D, Müller SA, et al. (December 2005). "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C". Molecular Cell. 20 (6): 867–879. doi:10.1016/j.molcel.2005.11.008. hdl:11858/00-001M-0000-0010-9405-4. PMID 16364912.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176248 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Tang_2001-5] 1 2 Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, et al. (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Molecular Biology of the Cell. 12 (12): 3839–3851. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.

[entrez-6] 1 2 "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".

[Vodermaier_2003-7] Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.

[Sumara_2000-8] Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

[Ohta_1999-9] Ohta T, Michel JJ, Schottelius AJ, Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Molecular Cell. 3 (4): 535–541. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407. S2CID 19371828.

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Interactions

References

External links

Further reading