ZBTB14

ZBTB14
Identifiers
Aliases	ZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14
External IDs	OMIM: 602126; MGI: 1195345; GeneCards: ZBTB14
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.31 Start 5,289,019 bp End 5,297,053 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 E1.3|17 40.42 cM Start 69,690,045 bp End 69,698,194 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon lymph node monocyte granulocyte ganglionic eminence gallbladder ventricular zone C1 segment gonad rectum Top expressed in ureter condyle Paneth cell ciliary body fossa medullary collecting duct lacrimal gland ascending aorta cumulus cell aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nucleolus cytosol aggresome Biological process cardiac septum development heart valve development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated coronary vasculature development transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7541 22666 Ensembl ENSG00000198081 ENSMUSG00000049672 UniProt O43829 Q08376 RefSeq (mRNA) NM_003409 NM_001143823 NM_001243702 NM_001243704 NM_009547 NM_001356282 NM_001356283 RefSeq (protein) NP_001137295 NP_001230631 NP_001230633 NP_003400 NP_033573 NP_001343211 NP_001343212 Location (UCSC) Chr 18: 5.29 – 5.3 Mb Chr 17: 69.69 – 69.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger and BTB domain-containing protein 14 is a protein that in humans is encoded by the ZBTB14 gene (previously ZFP161). The ZBTB14 protein acts as a transcription activator for the dopamine transporter, while instead acting as a transcription repressor for FMR1, MYC, and thymidine kinases.

See also

• Chromosome 18 (human)
• Sequence homology
• Zinc finger
• BTB/POZ domain

Further reading

• Numoto M, Niwa O, Kaplan J, et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMC 309887. PMID 8367294.
• Sugiura K, Muro Y, Nagai Y, et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta. 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-6. PMID 9177479.
• Obata T, Yanagidani A, Yokoro K, et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
• Numoto M, Yokoro K, Koshi J (1999). "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. doi:10.1006/bbrc.1999.0375. PMID 10080939.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lee KH, Kwak YD, Kim DH, et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang J, Kudoh J, Takayanagi A, Shimizu N (2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
• Orlov SV, Kuteĭkin-Tepliakov KB, Grishin AV, et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia. 48 (3): 246–52. PMID 16805315.
• Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511. S2CID 31019370.