Wrch1

RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene.^[1] RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.^[2]

References

↑ Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001). "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1". Genes Dev. 15 (14): 1796–807. doi:10.1101/gad.894301. ISSN 0890-9369. PMC 312736. PMID 11459829.
↑ Boureux A, Vignal E, Faure S, Fort P (2007). "Evolution of the Rho family of ras-like GTPases in eukaryotes". Mol Biol Evol. 24 (1): 203–16. doi:10.1093/molbev/msl145. ISSN 0021-9193. PMC 2665304. PMID 17035353.

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[Tao-1] Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001). "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1". Genes Dev. 15 (14): 1796–807. doi:10.1101/gad.894301. ISSN 0890-9369. PMC 312736. PMID 11459829.

[Boureux-2] Boureux A, Vignal E, Faure S, Fort P (2007). "Evolution of the Rho family of ras-like GTPases in eukaryotes". Mol Biol Evol. 24 (1): 203–16. doi:10.1093/molbev/msl145. ISSN 0021-9193. PMC 2665304. PMID 17035353.

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[2]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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References