WDHD1

WDHD1
Identifiers
Aliases	WDHD1, AND-1, CHTF4, CTF4, AND1, WD repeat and HMG-box DNA binding protein 1, Ctf4
External IDs	OMIM: 608126; MGI: 2443514; HomoloGene: 56019; GeneCards: WDHD1; OMA:WDHD1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D7L
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,027,105 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,514,314 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; testicle; ; ganglionic eminence; ; secondary oocyte; ; stromal cell of endometrium; ; epithelium of colon; ; mucosa of transverse colon; ; bone marrow cell; ; Achilles tendon;
	Top expressed in
	otic placode; ; otic vesicle; ; primitive streak; ; saccule; ; tail of embryo; ; epiblast; ; genital tubercle; ; ventricular zone; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA binding; chromatin binding; RNA binding; RNA polymerase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm; chromosome, centromeric region; replication fork protection complex; nuclear replication fork;
Biological process	RNA processing; regulation of chromosome organization; regulation of transcription by RNA polymerase II; mitotic cell cycle; DNA-dependent DNA replication; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	11169
	218973
	ENSG00000198554
	ENSMUSG00000037572
	O75717
	P59328
	NM_001008396; NM_007086
	NM_172598; NM_001360532
	NP_001008397; NP_009017
	NP_766186; NP_001347461
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene.^[5]

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198554 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037572 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WD repeat and HMG-box DNA binding protein 1". Retrieved 2013-02-18.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198554 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037572 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WD repeat and HMG-box DNA binding protein 1". Retrieved 2013-02-18.

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References