USP33

USP33
Identifiers
Aliases	USP33, VDU1, ubiquitin specific peptidase 33
External IDs	OMIM: 615146; MGI: 2159711; HomoloGene: 8996; GeneCards: USP33; OMA:USP33 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UZG
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.19.12 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.1 Start 77,695,987 bp End 77,759,852 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 H3 Start 152,052,115 bp End 152,099,254 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis Brodmann area 23 retinal pigment epithelium pons lateral nuclear group of thalamus mucosa of paranasal sinus parietal pleura primary visual cortex endothelial cell middle temporal gyrus Top expressed in neural layer of retina ventromedial nucleus lobe of cerebellum ventral tegmental area mammillary body dorsomedial hypothalamic nucleus pontine nuclei habenula lateral hypothalamus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity ubiquitin binding protein binding thiol-dependent deubiquitinase cysteine-type endopeptidase activity hydrolase activity G protein-coupled receptor binding Cellular component cytoplasm cell body centrosome Golgi apparatus VCB complex focal adhesion nucleoplasm microtubule organizing center autophagosome perinuclear region of cytoplasm cytoskeleton cytosol Biological process endocytosis protein K48-linked deubiquitination ubiquitin-dependent protein catabolic process regulation of G protein-coupled receptor signaling pathway centrosome duplication cellular response to starvation protein stabilization negative regulation of protein binding proteolysis axon guidance regulation of autophagy protein K63-linked deubiquitination positive regulation of protein binding cell migration protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23032 170822 Ensembl ENSG00000077254 ENSMUSG00000025437 UniProt Q8TEY7 Q8R5K2 RefSeq (mRNA) NM_015017 NM_201624 NM_201626 NM_001076676 NM_001252486 NM_133247 NM_001355666 RefSeq (protein) NP_055832 NP_963918 NP_963920 NP_001364359 NP_001364360 NP_001364361 NP_001364362 NP_001364363 NP_001364364 NP_001364365 NP_001364366 NP_001364367 NP_001364368 NP_001070144 NP_001239415 NP_573510 NP_001342595 Location (UCSC) Chr 1: 77.7 – 77.76 Mb Chr 3: 152.05 – 152.1 Mb PubMed search
Wikidata
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Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.

Interactions

USP33 has been shown to interact with DIO2, SELENBP1 and Von Hippel–Lindau tumor suppressor.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
• Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
• Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394.