Trichodiene synthase
| trichodiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.6 | ||||||||
| CAS no. | 101915-76-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction
- (2E,6E)-farnesyl diphosphate trichodiene + diphosphate
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.
Structural studies
[edit]As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1YJ4, PDB: 1YYQ, PDB: 1YYR, PDB: 1YYS, PDB: 1YYT, PDB: 1YYU, PDB: 2AEK, PDB: 2AEL, and PDB: 2AET.
References
[edit]- Hohn TM, Vanmiddlesworth F (1986). "Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides". Arch. Biochem. Biophys. 251 (2): 756–61. doi:10.1016/0003-9861(86)90386-3. PMID 3800398.[dead link]
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