Trichodermin
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| Names | |
|---|---|
| IUPAC name
12,13-Epoxytrichothec-9-en-4β-yl acetate | |
| Systematic IUPAC name
(2R,2′S,4R,5S,5aR,9aR)-5,5a,8-Trimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[[2,5]methano[1]benzoxepine-10,2′-oxiran]-4-yl acetate | |
| Identifiers | |
3D model (JSmol) |
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| 6868411 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| KEGG | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C17H24O4 | |
| Molar mass | 292.37 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Trichodermin is a trichothecene.[1] It inhibits protein formation in Euchariotes.[2]
References
[edit]- ↑ Wei, Cha-mer; Hansen, Bent S.; Vaughan, Maurice H.; McLaughlin, Calvin S. (March 1974). "Mechanism of Action of the Mycotoxin Trichodermin, a 12,13-Epoxytrichothecene". Proceedings of the National Academy of Sciences. 71 (3): 713–717. Bibcode:1974PNAS...71..713W. doi:10.1073/pnas.71.3.713. PMC 388083. PMID 4522785.
- ↑ Carrasco, L.; Barbacid, M.; Vazquez, D. (June 1973). "The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomes". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 312 (2): 368–376. doi:10.1016/0005-2787(73)90381-X. PMID 4579233.