Talk:Ropinirole

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Untitled

Latest comment: 11 years ago1 comment1 person in discussion

The synthesis figure seems to be of a different compound - maybe someone can fix it? 24.6.4.12 (talk) 05:41, 21 October 2014 (UTC)Reply

Binding affinity

Latest comment: 10 years ago1 comment1 person in discussion

The article states: "Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2". But the source (http://www.sciencedirect.com/science/article/pii/009130579190603Y) for this claim does not mention ropinirole's affinity for the D3 receptor. This source (http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2005.tb00046.x/pdf) claims ropinirole has a 20 fold higher affinity for D3 over D2. That makes me think the affinity is highest for the D3, not D2 as the article states. Which would be higher than even pramipexole, I think. This may be relevant, because D3 is said to be implicated in compulsive behaviors and anhedonia. Maybe someone has detailed info about ropinirole's binding affinity. I'm just a layperson. — Preceding unsigned comment added by Broomattack (talk • contribs) 09:45, 20 October 2015 (UTC)Reply

This page was redesigned at the edge.

Untitled

Binding affinity