Talk:Osteoporosis

Content of recent edits by ip 86.52.73.157

@ip editor: Thank you for your constructive contributions [please also see User talk:86.52.73.157]. I'm moving these recent, constructive additions to the talk page here as they have several problematic aspects in their current form (including some syntax and comprehensibility issues). In brief:

• The most recent addition appears to be partially off-topic, and the on-topic content would need to be supported by reliable medical sourcing such as a *review* article (rather than a primary source) in a trusted medical journal:

== Pollution-related osteoporosis ==

One of the health concerns with nitric oxides in particular, beside its manifestation in the global heating process, is, that an ethnically diverse cohort of 161,808 postmenopausal women who participated in a study published in 2023 found nitric oxides to be, a major contributor to bone deterioration in postmenopausal women, with one in two women over 50 years who experience a bone fracture, the lumbar spine is one of the most susceptible sites to damage from the oxides, and found to be twice as destructive as normal aging, with effects thought to occur through bone cell death by oxidative stress and other mechanisms. For example, lumbar spine bone mineral density (BMD) decreased 0.026 g/cm2/year per 10% increase in 3-year mean NO₂ concentration, or amount to 1.22% annual reductions, nearly twice the annual effect of age at any of the anatomical sites assessed.

• I think the other addition/s could potentially form part of a ==Research directions== section (if due attention is paid to editorial weight):

==== Screening for the CB2 gene ====

The cannabinoid receptor 2 gene, encoding the CB2-receptor, a receptor that is part of the endocannibinoid system, which also comprise the CB1-receptor present in sympathetic nerve terminals in the vicinity to osteoblasts where it communicates brain-to-bone signals and stimulating bone formation, and the CB2 expressed by osteoblasts and osteoclasts in women, is found associated with low bone mineral density, and a useful receptor to screen for, to identify females at risk of developing osteoporosis, as mice with deficient display of the CB2, show a markedly accelerated age-related bone loss, and its activation stimulates bone formation and suppresses bone resorption, and further, by a CB2-receptor agonist, bone loss can be prevented and rescued. ...

In addition, preclinical and clinical studies investigating the effects of cannabis and/or its constituents, as well as activation (agonist) or inactivation (antagonist) of cannabinoid receptor 1 and 2, and its role in bone remodeling (bone metabolism) have shown that the effects of cannabis mediated through the endocannabinoid system, may prove to be an effective treatment option for people with osteoporosis.

@Headbomb: fyi. @WhatamIdoing: I hope this appropriate[?]

References

86.172.7.207 (talk) 19:57, 25 October 2024 (UTC)

I noticed this and also thought that it would be best if we could work together on the talk page to develop content that is appropriate using high quality secondary sources. I noted that the main ref in the pollution improvement suggested was a prospective observational study. Great that this work has been saved here on the talk page so we can find high quality secondary sources to develop a section (if appropriate).JenOttawa (talk) 20:09, 25 October 2024 (UTC)

The other source used in the pollution section is from ScienceDaily https://www.sciencedaily.com/releases/2023/02/230221132129.htm and summarizes the same prospective observational study. Are there any systematic reviews on this in PubMed? In my opinion, these references should be replaced by a higher quality secondary source. JenOttawa (talk) 20:12, 25 October 2024 (UTC)

The idea that air pollution causes osteoporosis would need a better source than what's listed above. Since the cited sources are (mostly?) from 2023, that might exist by now.

I don't understand what the CB2 gene paragraph is driving at. In plain English, is this more of the usual about marijuana practically being a panacea? Is this supposed to be about certain mutations in the gene (which is a thing that could be screened for) or about the level of expression of this gene (which could change over time/circumstance)? WhatamIdoing (talk) 20:14, 25 October 2024 (UTC)

I agree that the pollution section should not be added back in without high quality sources.JenOttawa (talk) 02:40, 26 October 2024 (UTC)

Hi You

I was sorry to see, that the information was removed and I did something wrong, or the information is not of interest or proper to this page on Wikipedia. I was not done adding information, but would like to continue today, to complete information with links to more credible sources to it, and to make all information relate to each other. I would of course like to see the information back, somewhere on the page where You think it belongs, and if not, I wish You all the best in the future. A little about new information

It is polymorphisms in CNR2, the gene encoding CB2, that are strongly associated with postmenopausal osteoporosis, and thereby to have diagnostic measures to identify osteoporosis-susceptible polymorphisms in CNR2(1,2)

References

1. Endocannabinoids and the Regulation of Bone Metabolism. Journal of Neuroendocrinology Volume 20, Issues 1, Special Issue: Here, There and Everywhere: the Endocannabinoid System. May 2008. Pages 69-74
2. Cannabinoids and the skeleton: From marijuana to reversal of bone loss. Itai Bab, Andreas Zimmer, Eitan Melamed. Ann Med.. 2009;41(8):560-7. DOI: 10.1080/07853890903121025 - Bone Laboratory, the Hebrew University of Jerusalem, Jerusalem, Israel.

Hope this information help to explain the misunderstanding of, what I would consider, new useful informative old news, and no, this is not more of the usual about marijuana practically being a panacea? - IT IS, for the vast majority, of everything related to it, even You or I like it, or not, it can, as it seems like, help people with osteoporosis through the endocannabinoid system, by a CB2-specific agonist found to rescue ovariectomy-induced bone loss, and the CB1 to communicates brain-to-bone signals and stimulating bone formation.

And, very important to know, at the same time medicating, one is/get protected by the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases, as all the cannabinoids in Cannabis, by the Patent of US Department of Health and Human Services in 1998/04/21, are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia, (1) because all cannabinoids of the cannabis plant are very strong antioxidants and neuroprotectants, and protect neurons to a greater extent than any of the dietary antioxidants, tocopherol (Vitamin E) or ascorbate (Vitamin C), and protects neurons with comparable effectiveness to the potent antioxidant BHT (butylhydroxytoluene). (2) And by this, it/they, at the same time, protect against bone cell death by oxidative stress seen in pollution-related osteoporosis.

In addition, when the plant is grown for, among other things, extraction of medical and preventive drugs, the cannabis plant during growth is able to remove more CO2 from the surrounding carbon cycle than it emits, where the production of biomass produces between 8 and 12 tons of CO2, but seizes in the stems between 10 and 15 tons per hectare, and with the possibility of sequestering up to 22 tonnes of CO2.(3). This means that this grown medicine also, at the same time, help in the global heat scenario, caused by pollution and nitric oxides NO₂ concentration. A major contributor to bone deterioration in postmenopausal women, with one in two women over 50 years who experience a bone fracture, the lumbar spine is one of the most susceptible sites to damage from the oxides, and found to be twice as destructive as normal aging, with effects thought to occur through bone cell death by oxidative stress.

Referencer

1. Cannabinoids as antioxidants and neuroprotectants, Inventor: Aidan J. Hampson, Julius Axelrod, Maurizio Grimaldi. Current Assignee: US Department of Health and Human Services. Priority: 1998/04/21 Grant: 2003/10/07

2. Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Aidan John Hampson, Maurizio Grimaldi, J Axelrod, David A Wink et al., Proc Natl Acad Sci U S A. 1998 Jul 7; 95(14): 8268–8273.

3. "Introduction to emerging industrial applications of cannabis (Cannabis sativa L.)"doi10.1007/s12210-021-00979-1, Rendiconti Lincei. Scienze Fisiche e Naturali. 32 (2): 233–243. (1 June 2021)

4. Components of the Endocannabinoid System and Effects of Cannabinoids Against Bone Diseases: A Mini-Review

Yuqi Xin et al. Front. Pharmacol., 19 January 2022. - Sec. Experimental Pharmacology and Drug Discovery Volume 12 - 2021

"Many studies have demonstrated that endocannabinoids (eCBs) and cannabinoid receptors (CBRs) are expressed in bone and synovial tissues, playing important roles in bone metabolism. Preclinical studies using cannabis-based therapies in animal models have shown that cannabinoids (CBs) can alleviate the development of osteoarthritis (OA), prevent osteoporosis (OP), reduce cancer-induced osteolytic destruction, and improve fracture healing, highlighting the therapeutic potential of CBs for human bone diseases"

5. Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review. Journal of Pharmacy and Pharmacology, Volume 71, Issue 10, October 2019, Pages 1469–1474, https://doi.org/10.1111/jphp.13135 Published: 11 July 2019

Etcetera, and there is more

Changed to: In addition, preclinical and clinical studies investigating the effects of cannabis and/or its constituents,[176][177] as well as activation or inactivation of cannabinoid receptor 1 and 2, and its role in bone remodeling (bone metabolism) have shown that the effects of cannabis mediated through the endocannabinoid system, may prove to be an "effective" treatment option for people with osteoporosis, (4 [Cannabinoids and the skeleton: From marijuana to reversal of bone loss] and at the same time counteract other age-related neurological diseases, (* 1,2) and in addition, global warming, as the plant during growth is able to remove more CO2 from the surrounding carbon cycle than it emits, where the production of biomass produces between 8 and 12 tons of CO2, but seizes in the stems between 10 and 15 tons per hectare, and with the possibility of sequestering up to 22 tons of CO2 per hectare [176; 3]

Have a nice day 86.52.73.157 (talk) 18:43, 26 October 2024 (UTC)

First, please read up on WP:PATENTS.

Second, that's not what an encyclopedia summary should sound like. An encyclopedia summary might sound like this (varying the wording to match the actual facts as needed):

• "Some research is being done on whether cannabis consumption could prevent osteoporosis in post-menopausal women with certain high-risk genetic mutations."
• "There is a correlation between air pollution and osteoporosis."

A summary needn't be a single sentence, but it should be an overview, not the nitty-gritty details. WhatamIdoing (talk) 00:33, 27 October 2024 (UTC)

Supplemental 3D resource for bone microarchitecture

I’d like to propose a link to a professional 3D clinical overview of osteoporosis: Osteoporosis: 3D Pathology and Clinical Overview.

This resource includes a unique side-by-side 3D comparison of an unaltered T11 vertebra and a T12 vertebra affected by osteoporosis (showing disrupted trabecular structure). It also visualizes a T10 compression fracture, offering a more intuitive understanding of the bone density loss discussed here.

Disclosure: Affiliated with Voka.io. Valiantsinas (talk) 18:54, 10 April 2026 (UTC)

 Not done - Although the 3D VOKA images are attractive, the website is advertising a business, WP:PROMO, and is not a WP:MEDRS review or clinical guideline. Zefr (talk) 19:25, 10 April 2026 (UTC)