Talk:Hemoglobin

Decay Time

How long does it take for hemoglobin to decay if blood falls out of a slaughtered animal onto the ground (or someplace not in the animal)? Chiss Boy 12:34, 4 March 2007 (UTC)

Google it? MaximusEditor (talk) 07:14, 1 October 2020 (UTC)

Consistency

This article goes back and forth between hemoglobin and haemoglobin. Pick one and stick with it, but mention both in the first sentence. I believe the hemoglobin spelling is more universal throughout medical literature, but I don't know about common usage outside the US. Hichris 17:39, 16 December 2005 (UTC)

It was pretty uniform at "hemoglobin" until this was changed . My literature might have been american, but I think hemoglobin is the one to choose. / Habj 03:46, 17 December 2005 (UTC)

I would prefer hæmoglobin! That is the traditional spelling. Failing that, then haemoglobin. It's only in North America that the "simplified" version is used. EuroSong ^talk 09:30, 2 November 2006 (UTC)

I guess haemoglobin would be better as it is the traditional spellingVik4989 06:25, 5 August 2007 (UTC)

You only went back a month. Had you gone back to January, you would see the Haemoglobin spelling the article first began with was still "pretty uniform". 2001:8004:5160:17E8:B7F4:593E:152D:6CFC (talk) 11:58, 9 May 2023 (UTC)

Yeah we should really be using haemoglobin. —Preceding unsigned comment added by 194.81.199.59 (talk) 16:44, 11 February 2008 (UTC)

Hemoglobin is the spelling far more commonly used in scientific literature. Searching Medline turns up ~76,000 hits for "hemoglobin" and under 20,000 for "haemoglobin." —Preceding unsigned comment added by 128.237.250.128 (talk) 20:32, 24 April 2008 (UTC)

The Lancet gives 18 results for hemoglobin, and 1596 results for haemoglobin... —Preceding unsigned comment added by 86.150.188.15 (talk) 14:35, 23 January 2011 (UTC)

As the World Health Organisation uses the spelling "haemoglobin" would it not be more correct to use that spelling? —Preceding unsigned comment added by 78.144.149.123 (talk) 21:33, 16 February 2011 (UTC)

I tried a redirect but some automated process is not letting me to add the content to the Haemoglobin part. Some one fix it! 61.3.151.103 (talk) 09:52, 29 July 2018 (UTC)

Discovery?

I don't know about this edit. If we've got a source that says 1851, then why are we replacing it with one that asserts a 1940 discovery? WhatamIdoing (talk) 20:11, 8 January 2009 (UTC)

It depends what you mean by discovery. Observation? Isolation? Structure? — Preceding unsigned comment added by Carstensen (talk • contribs) 15:30, 5 December 2011 (UTC)

From the paragraph headed Research History:

In 1825 J. F. Engelhard discovered that the ratio of iron to protein is identical in the hemoglobins of several species.

Not a claim of discovery, but a fairly strong implication that someone else had already discovered hæmoglobin; granted, Engelhard did not use that term but instead called it vera materia sanguini purpureum colorem.

I found this on an American Chemical Society webpage (https://www.acs.org/content/acs/en/molecule-of-the-week/archive/h/hemoglobin.html):

Here are some significant events in the history of hemoglobin discovery:

1825: J. F. Engelhard shows that the Fe/protein ratio is the same in several species’ hemoglobin.

1840: F. L. Hünefeld discovers that hemoglobin transports oxygen.

I think that makes "protein" a likely typo for "property of" in the bit about Hünefeld, but I do not have access to the primary sources. Regardless, for Engelhard to have come up with such a close (and, at the time, astonishing) estimate for the molecular mass of hæmoglobin deserves a much wider currency.

I'm going to make the edit and see what turns up. Moletrouser (talk) 10:21, 23 September 2018 (UTC)

Origin of the word "hemoglobin"

Based on a quick check of an online dictionary, the word "heme" was first used in 1925, well after the use of "hemoglobin". I would "guess" that the word is based on "hemo-" (blood) and "globin" (roundish protein) and was called that before heme was discovered, but I don't have a reference source to verify this. Anyone else have a specific reference for this? --Kris (talk) 17:18, 30 December 2011 (UTC)

The Online Etymology Dictionary says: hæmoglobin, coloring matter in red blood cells, 1862, shortening of hæmatoglobin (1845), from Greek haimato-, combining form of haima (genitive haimatos) "blood" (see -emia) + globulin, a type of simple protein, from globule, formerly a word for "corpuscle of blood." For haemo- it says word-forming element meaning "blood," perhaps via Old French hemo-, Latin haemo-, from Greek haimo-, contraction of haimato-, combining form of haima "blood" (see -emia). 2001:8004:5160:17E8:B7F4:593E:152D:6CFC (talk) 11:58, 9 May 2023 (UTC)

Cooperative Binding

It might be helpful to include some mention of the T and R states in this section. It does address the change in conformation, but specificity is always preferred. Dykeszr (talk) 14:37, 6 April 2017 (UTC)Dykeszr

The graphic shows the change from T to R state, which is really informative so I believe that inclusion of the specific states and some information on them would benefit the page AshleyJennings (talk) 18:13, 14 October 2020 (UTC)

Requested move 29 July 2018

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review. No further edits should be made to this section.

The result of the move request was: no consensus to move the page to the proposed title at this time, per the discussion below. Dekimasuよ! 06:19, 5 August 2018 (UTC)

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Hemoglobin → HaemoglobinHaemoglobin – The preferred title has been discussed informally before, but it seems like it is time for a formal move discussion after a recent cut'n'paste move attempt. Haemoglobin is the traditional spelling, but hemoglobin is arguably now more common. See discussion above. Lithopsian (talk) 11:30, 29 July 2018 (UTC)

• The title was discussed in this section above and its worth a look before commenting here. There could be WP:ENGVAR/MOS:RETAIN issues here ("...use the variety found in the first post-stub revision that introduced an identifiable variety."). The article text was had some British English using "haemoglobin" including in the intro, but it wasn't consistent. Page moves (title moves) did not appear in early edit history summaries, but the creation date of this redirect and this edit in 2005 show that the original title was likely hemoglobin. —  AjaxSmack  17:04, 29 July 2018 (UTC)
• Support dominant spelling in GBooks In ictu oculi (talk) 17:28, 29 July 2018 (UTC)
  • Absolutely is not - Hemoglobin nets over 5 million results and Haemoglobin has has just 2 million. Google Ngram link below proves it further. -- Netoholic @ 11:43, 30 July 2018 (UTC)
    • Since when Google search is a factor to consider in deciding those? 117.197.195.103 (talk) 13:44, 1 August 2018 (UTC)
      • I suggest you read WP:TITLE. Natureium (talk) 13:56, 1 August 2018 (UTC)
• Oppose Haemoglobin is not clearly dominant. Natureium (talk) 19:40, 29 July 2018 (UTC)
• Oppose current name is obviously most common per Google Ngram results and Google Scholar comparison ("Hemoglobin" at 1870k and Haemoglobin at 582k). Such WP:COMMONNAME usage means that other WP:CRITERIA are not met by this move proposal, and it would be a disservice to readers and editors. -- Netoholic @ 11:43, 30 July 2018 (UTC)
• Oppose per WP:COMMONNAME. 14:56, 30 July 2018 (UTC)
• Support I'm a med student in the US and even we don't use 'Hemoglobin'. In all our academic books, it's haemoglobin. 'Haemoglobin' is the standard spelling. 117.197.195.103 (talk) 13:44, 1 August 2018 (UTC)

That's interesting, because based on your IP address, you're editing from India. Natureium (talk) 13:56, 1 August 2018 (UTC)

That's about right. If I am in India, I'd be using an Indian IP only. What does this have to do with my point? 103.207.247.156 (talk) 09:27, 2 August 2018 (UTC)

You just said you're a medical student in the US. Which really isn't relevant anyway. Not all medical schools use the same textbooks. Natureium (talk) 14:38, 2 August 2018 (UTC)

US medical schools have summer breaks right about now...Which really isn't relevant anyway. —  AjaxSmack  22:42, 2 August 2018 (UTC)

It's all different. Ours started back this week. Natureium (talk) 22:45, 2 August 2018 (UTC)

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The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page or in a move review. No further edits should be made to this section.

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 6 October 2020 and 16 December 2020. Further details are available on the course page. Peer reviewers: AshleyJennings.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:17, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 12 August 2020 and 25 November 2020. Further details are available on the course page. Student editor(s): JoyousMuse.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 23:19, 16 January 2022 (UTC)

"Iron's oxidation state in oxyhemoglobin" too much information?

Would anyone be opposed to me cleaning up and shortening the section on the oxidation state? It's all good information, but it's something of a rabbit hole that is probably not of interest (or accessible) to a general audience. I think it could all be summarized in a paragraph, pointing out the conflicting models and stating that there is disagreement about the matter. If there is general consensus to keep it the way it is, I'll shut up. WeirdNAnnoyed (talk) 03:04, 18 April 2023 (UTC)

I deleted the section entirely: It was far too detailed, was packed with WP:SYNTH, cited few sources, and at least one of the cited sources did not mention hemoglobin at all. I simply added a brief summary of the main points, cited to an appropriate secondary source, under the "oxyhemoglobin" section above. WeirdNAnnoyed (talk) 18:36, 12 July 2023 (UTC)

Do these numbers add up?

From this article:

A healthy human has 12 to 20 grams of hemoglobin in every 100 mL of blood ... in mammals, hemoglobin makes up about 96% of a red blood cell's dry weight (excluding water), and around 35% of the total weight (including water).

From the article blood:

Blood accounts for 7% of the human body weight, with an average density around 1060 kg/m3

1060 kg/m3 = 106g per 100 mL
35% of 106g = 37g, well outside stated the range 12 to 20 grams

Sorry, I overlooked that 35% is for a blood cell, not blood as a whole.

Another thing, isn't it weird to give the density of blood in kg/m3? Wouldn't g/cm3 be more normal? 2A00:23C8:7B09:FA01:2165:E410:E554:7951 (talk) 18:09, 25 February 2024 (UTC)

Wiki Education assignment: BYU-Biophysics, CELL 568

This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 September 2024 and 18 December 2024. Further details are available on the course page. Student editor(s): Girlwholovesscience (article contribs). Peer reviewers: TheDutch1313, ColtCosmo.

— Assignment last updated by TheDutch1313 (talk) 16:31, 10 October 2024 (UTC)

Advertising for Detalo?

The very similar contributions from user Bechlund to Blood volume and Hemoglobin sound like an ad for Detalo, backed with a reference to a scientific paper. That paper was co-authored by Detalo’s co-founder Carsten Lundby, and user Bechlund probably is Jonas Bechlund, also a co-founder. This reeks of a conflict of interests. -- 78.23.192.69 (talk) 22:23, 15 November 2024 (UTC)

Good catch. I just removed the promotional text, but kept the reference since the first few sentences are useful. WeirdNAnnoyed (talk) 12:00, 16 November 2024 (UTC)

Thanks for the feedback and action. I copied your edit on Blood volume.

-- 78.23.192.69 (talk) 22:23, 18 November 2024 (UTC)