Talk:G418

got rid of this redirect below --- Dudes, G418 is *not* Hygromcin

'REDIRECT Hygromycin B'

Its proper name is Geneticin

G418 is: C₂₀H₄₀N₄O₁₀

IUPAC Name: (2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2R,3R,4R,5R)-3 ,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-2- (1-hydroxyethyl)oxane-3,4-diol Canonical SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O

Hygromyin B is: C20H37N3O13 IUPAC Name: (3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydrox y-5-methylaminocyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxyme thyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-d]pyran-2,2'-oxane]-3', 4',5',7-tetrol Canonical SMILES: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

user:mxpule

thank you for posting this--Ozzie10aaaa (talk) 13:58, 7 March 2023 (UTC)

Incorrect structural image

The structural image provided is incorrect. The 4,6-disubstituted-2-deoxystreptamine scaffold is correct, but the substituted groups are flipped. The sugar with the secondary amine should be at the top. See the image provided by PubChem here (https://pubchem.ncbi.nlm.nih.gov/compound/Geneticin#section=2D-Structure). I would upload an updated image, but I do not have a working license of ChemDraw. I did not bother to check if the rest of the stereochemistry was correct but a correction should be made to the structural image by someone with a working ChemDraw license. YuYuTheYunicorn (talk) 20:44, 1 March 2023 (UTC)

will look--Ozzie10aaaa (talk) 13:57, 7 March 2023 (UTC)