Talk:FHL2
Add topicLatest comment: 7 months ago by AndGG97 in topic Epigenetics and aging
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[edit]Content was updated by expert on subject, formatting improved by Wikipedia community. This is no longer a stub. Gtsulab (talk) 16:34, 14 September 2015 (UTC)
Epigenetics and aging
[edit]FHL2’s promoter contains CpG sites that typically become hypermethylated with age, a modification that has been used as a marker in DNA methylation–based age prediction models, like epigenetic clocks.[1]
Targeted methylation editing at age-associated CpGs, including FHL2, has been reported to induce genome-wide “bystander” methylation changes at other age-associated CpGs, supporting the idea that epigenetic ageing marks may be coordinated across the genome. [2] AndGG97 (talk) 09:53, 9 December 2025 (UTC)
- ↑ Jung, Sang-Eun (29 September 2018). "DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples". Forensic Science International: Genetics. 38: 1-8. doi:10.1016/j.fsigen.2018.09.010. Retrieved 7 December 2025.
- ↑ Liesenfelder, Sven (24 Mar 2025). "Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape". Nature Aging. 5: 997–1009. doi:10.1038/s43587-025-00841-1. Retrieved 7 December 2025.