Talk:Dan Theodorescu

Significant recent Nature paper

Dr. Dan Theodorescu has recently published a paper in Nature (journal) titled "Y chromosome loss in cancer drives growth by evasion of adaptive immunity" Nature is a major journal and this paper ought to be added to the article. RKSatWork (talk) 17:22, 27 June 2023 (UTC)

This isn't a CV, we should not be listing everything he publishes. MrOllie (talk) 17:29, 27 June 2023 (UTC)

I agree completely, he has many publications, but this is an article in Nature which is one of the most important scientific journals. A publication in Nature is a major accomplishment. RKSatWork (talk) 20:47, 29 June 2023 (UTC)

It may be published in an important journal, but it does not follow that it inherits importance because of that. Nature publishes unimportant stuff from time to time just like any journal. Was there wide spread news coverage? Is the result being incorporated into textbooks? Is it cited much more often than other papers in its field? Those are indicators of importance. MrOllie (talk) 20:53, 29 June 2023 (UTC)

Here is the coverage so far. I have also been told by our Communications group that Dr. Theodorescu will be interviewed regarding the paper and research by our local Los Angeles ABC-TV news affiliate next week. I can provide a link to that once it airs.

Popular Science – Men lose Y chromosomes with age, and it might increase their risk of bladder cancer,

USA Today – What’s to blame for certain cancer outcomes? Studies confirm: Sex matters

Technology Networks – Loss of Y Chromosome May Help Bladder Cancers Grow

Healio Hem-Onc – Y chromosome loss may be key to unlocking more effective bladder cancer treatment for men

WKRG-TV – Some cells in older men lose Y chromosome,

KCBS Radio – Loss of Y chromosome linked to increased risk of cancer in older men,

KCBS-AM Online – Men lose their Y chromosome with age, and it could be dangerous,

HealthDay – Could Loss of the Y Chromosome Help Speed Cancers in Men?

IFL Science – Y Chromosome Loss Could Drive Cancer Growth in Males

The ASCO Post – Loss of Y chromosome in men and bladder cancer progression, RKSatWork (talk) 21:36, 29 June 2023 (UTC)

They're using the same quotes, a clear sign of press release churnalism. Not great. MrOllie (talk) 21:53, 29 June 2023 (UTC)

Popular Science and KCBS conducted their own interviews with Dr. Theodorescu. Some of the others did use quotes or other material directly from the Cedars-Sinai press release rather than conducting their own interviews.

I will post a link the ABC interview when it airs. Out of curiosity, how much media coverage is needed for a scientific article to considered important? RKSatWork (talk) 20:38, 30 June 2023 (UTC)

No amount, if it is the product of an overactive communications group and not genuine interest from the public. It is pretty clear what is going on here at this point - Wikipedia is not a promotional vehicle. Please do not treat it as one. MrOllie (talk) 00:48, 1 July 2023 (UTC)

This is a significant article based on the scientific feedback it has received and Nature seems to feel the article was worth highlighting on their recent podcast. Why bladder cancer cells that shed their Y chromosome become more aggressive (nature.com) Would they choose to do this if this article was part of that "unimportant stuff from time to time" that you say they publish? RKSatWork (talk) 00:41, 4 July 2023 (UTC)

Request for edits due to COI

i have moved institutions in 2025 and would appreciate is somebody could make this edit to the page: https://cancercenter.arizona.edu/news/2025/02/dan-theodorescu-md-phd-leads-u-cancer-center thank you

we also published another major discovery on the Y chromosome also in the journal Nature in 2025. this article was accompanied by two editorials. would appreciate somebody adding both this paper (2025) and the prior paper (2023) to the page. the links for the papers and two editorials are below. thank you

https://pubmed.ncbi.nlm.nih.gov/40468066/ https://www.nature.com/articles/d41586-025-01450-z https://pubmed.ncbi.nlm.nih.gov/40468118/ WikiPage26 (talk) 21:26, 20 February 2026 (UTC)

Request for edits

This LLM-generated text has been collapsed and should be excluded from assessments of consensus.

The following discussion has been closed. Please do not modify it.

I have a conflict of interest as the subject of this biography, and I am requesting this update for accuracy and completeness.

• • Proposed addition (with sources):**

In 2023 and 2025, Theodorescu was a senior author on two independent studies published in Nature that reported major discoveries on the biological and clinical significance of Y chromosome loss in cancer. One study demonstrated that mosaic loss of the Y chromosome in tumor cells was associated with adverse clinical outcomes and altered tumor–immune interactions. A subsequent study showed that Y chromosome loss can impair antitumor immune responses and influence treatment outcomes across cancer types.

These studies were accompanied by commissioned Nature editorials discussing their implications for cancer prognosis and therapy.

All sources are peer‑reviewed or editorial content from Nature. WikiPage26 (talk) 18:17, 26 March 2026 (UTC)

References

• Not done: your request appears to have been generated by a large language model. MediaKyle (talk) 16:04, 4 May 2026 (UTC)