Talk:Cefazolin

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Mog22, LeiC CP133 G22, KuangK CP133 G22. Peer reviewers: Toastntea21.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:02, 16 January 2022 (UTC)

IUPAC Name and Structure

The structure lacks stereochemistry. The name sis

(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

and the structure should be adjusted to include stereo--ChemSpiderMan (talk) 16:23, 25 May 2008 (UTC)

Added sections and references

Group 22 changes: -Lead: added trade name, moved mechanism of action into its own section. -Medical uses: added bulleted list of indications for infections, reduced surgery prophylaxis to single statement (there were no references for timing). -Bacterial susceptibility: removed MIC range, separated by gram negative and gram positive, and added statements. -Special populations: section added; then added neonates, elderly, and changes to pregnancy subsections. -Mechanism of action: section added. -Adverse events: added caution for patients experiencing bloody stools. -Brands: removed section. MeyerC G22 (talk) 02:40, 5 November 2015 (UTC)

UCSF Peer Review 11/09/2015 Neutral Point of View: Yes Verifiable Citations – Yes Recommendations: - Medical uses: Include external links - MOA: Expand on mechanism of action, such as how penicillin binding proteins work (or at least link to PBPs) - Susceptibilities: Provide bulleted list for what is not susceptible, consider separating out intrinsically resistant. - Side Effects: Comment on prevalence, so readers know what is common/rare and the red flags to look out for. Maybe put in % information and reorganize by common/chronic/rare-but-severe. Bulleted list may also help with readablity - Special population is good, maybe link “analphylaxis” to its wiki page to make it more layman-friendly

128.218.42.49 (talk) 20:00, 9 November 2015 (UTC)

Fact Check Interaction with alcohol

- Please verify the cited reference for this statement:

"As the antibiotic is broken down in the body, it releases free NMTD, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.[13] "

Cefazolin is excreted from the body unchanged. It is not broken down. Refs: https://www.drugbank.ca/drugs/DB01327, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e8f40f72-3cf0-43dc-a797-fb98dd8af228, — Preceding unsigned comment added by 205.193.94.40 (talk) 20:03, 10 January 2019 (UTC)

Uses

It can be used for both pneumonia and endocarditis occasionally per the reference.

Doc James (talk · contribs · email) 11:32, 4 November 2019 (UTC)

Wiki Education assignment: PHMD 2040 Service - Learning Spring 2023

This article was the subject of a Wiki Education Foundation-supported course assignment, between 2 January 2023 and 30 June 2023. Further details are available on the course page. Student editor(s): Jordynlazic, EriyanTurtle (article contribs).

— Assignment last updated by JustinxLane (talk) 19:04, 2 June 2023 (UTC)