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Latest comment: 7 years ago2 comments2 people in discussion
Does the letter after the 25 mean or stand for something, or is each compound just assigned an arbitrary letter from the alphabet in order? Is there a difference between 25B- compounds and 25C- compounds, and if so, what? Is it pronounced "twenty-five NB" or "two five NB"? Widsith (talk) 14:34, 16 May 2018 (UTC)Reply
The letter after the 25 stands for the substituent at the phenethyl 4-position, most of them correspond to the first letter of the name e.g. B = bromo, C = chloro, I = iodo, E = ethyl etc. However there are some oddballs resulting from the idiosyncratic naming of the 2C-x parent compounds, so D = methyl and T7 = propylthio for instance. The 25 is pronounced "two five" as it refers to the 2 and 5 methoxy groups on the phenyl ring (though most people would probably understand if you said "twenty five B" that you meant 25B-NBOMe). The NB stands for N Benzyl then at the end is the benzyl substituent which is at the 2-position by default, so N-(2-methoxybenzyl) becomes NBOMe, N-(2-fluorobenzyl) becomes NBF etc. If the benzyl substituent is not at the 2-position then an extra number is added, e.g. N-(3-methoxybenzyl) is NB3OMe. Meodipt (talk) 07:45, 27 April 2019 (UTC)Reply
