TYRO3

TYRO3
Identifiers
Aliases	TYRO3, BYK, Dtk, RSE, Sky, Tif, Etk-2, Rek, TYRO3 protein tyrosine kinase
External IDs	OMIM: 600341; MGI: 104294; HomoloGene: 4585; GeneCards: TYRO3; OMA:TYRO3 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RHF
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.10.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 41,557,675 bp End 41,583,589 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E5|2 59.97 cM Start 119,628,214 bp End 119,648,585 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 paraflocculus of cerebellum middle frontal gyrus right hemisphere of cerebellum right frontal lobe Brodmann area 9 cerebellar vermis C1 segment cingulate gyrus Top expressed in primary motor cortex perirhinal cortex olfactory epithelium piriform cortex olfactory tubercle superior frontal gyrus entorhinal cortex cingulate gyrus prefrontal cortex primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity virus receptor activity kinase activity phosphatidylinositol 3-kinase binding protein binding protein heterodimerization activity ATP binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor tyrosine kinase transmembrane signaling receptor activity Wnt-protein binding Cellular component integral component of membrane nuclear envelope endoplasmic reticulum membrane membrane plasma membrane integral component of plasma membrane nucleus cell surface cytoplasm receptor complex Biological process vagina development phosphorylation negative regulation of lymphocyte activation protein phosphorylation viral entry into host cell phosphatidylinositol 3-kinase signaling protein autophosphorylation viral process signal transduction natural killer cell differentiation cell adhesion negative regulation of innate immune response spermatogenesis platelet activation forebrain cell migration apoptotic cell clearance substrate adhesion-dependent cell spreading peptidyl-tyrosine phosphorylation ovulation cycle negative regulation of neuron apoptotic process platelet aggregation neuron cellular homeostasis protein kinase B signaling negative regulation of toll-like receptor signaling pathway secretion by cell negative regulation of inflammatory response neuropeptide signaling pathway negative regulation of signal transduction Wnt signaling pathway cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7301 22174 Ensembl ENSG00000092445 ENSMUSG00000027298 UniProt Q06418 P55144 RefSeq (mRNA) NM_006293 NM_001330264 NM_001290800 NM_019392 RefSeq (protein) NP_001317193 NP_006284 NP_001277729 NP_062265 Location (UCSC) Chr 15: 41.56 – 41.58 Mb Chr 2: 119.63 – 119.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.

Interactions

TYRO3 has been shown to interact with:

• GAS6, and
• PIK3R1

Further reading

• Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. doi:10.1016/S0021-9258(17)34118-2. PMID 7511603.
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. Bibcode:1995BBRC..209..656T. doi:10.1006/bbrc.1995.1549. PMID 7537495.
• Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC, Crosier PS (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors. 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658.
• Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene. 9 (3): 699–705. PMID 8108112.
• Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene. 9 (3): 975–9. PMID 8108143.
• Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA, Guida LC, Nicholls RD, Alitalo K (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene. 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388.
• Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.
• Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360.
• Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.
• Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T, Ohno K, Takashima S, Onodera K (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell. 88 (1–2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267. S2CID 31494402.
• Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood. 95 (2): 633–8. doi:10.1182/blood.V95.2.633. PMID 10627473.
• Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3 (inactive 20 October 2025). PMID 12768229. S2CID 13419387.{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)
• Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883.
• Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.
• Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779.
• Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.