TRIM31

TRIM31
Identifiers
Aliases	TRIM31, C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31
External IDs	OMIM: 609316; MGI: 2385051; HomoloGene: 17137; GeneCards: TRIM31; OMA:TRIM31 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSJ, 2YSL
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,113,090 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	37,221,106 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; appendix; ; gallbladder; ; urinary bladder; ; testicle; ; epithelium of colon; ; right testis; ; left testis;
	Top expressed in
	intestinal villus; ; jejunum; ; duodenum; ; left colon; ; ileum; ; epithelium of small intestine; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; migratory enteric neural crest cell; ; zygote;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; transferase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; mitochondrion;
Biological process	positive regulation of DNA-binding transcription factor activity; protein ubiquitination; interferon-gamma-mediated signaling pathway; negative regulation of viral transcription; innate immune response; negative regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	11074
	224762
ENSG00000223531; ENSG00000137397; ENSG00000233573; ENSG00000224168; ENSG00000225130;
	ENSG00000226402; ENSG00000224542; ENSG00000204616
	ENSMUSG00000058063
	Q9BZY9; Q2L6J1
	Q8R0K2
	NM_007028
	NM_146077
	NP_008959; NP_008959.3
	NP_666189
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.^[5]^[6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.^[6]

Interactions

TRIM31 has been shown to interact with TRIM23.^[5]

References

1 2 3 ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058063 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
1 2 "Entrez Gene: TRIM31 tripartite motif-containing 31".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID 8490624.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058063 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] 1 2 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] 1 2 "Entrez Gene: TRIM31 tripartite motif-containing 31".

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TRIM31

Interactions

References

Further reading