TNIP2

TNIP2
Identifiers
Aliases	TNIP2, ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2
External IDs	OMIM: 610669; MGI: 2386643; HomoloGene: 11515; GeneCards: TNIP2; OMA:TNIP2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 2,741,648 bp End 2,756,342 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B2 Start 34,653,431 bp End 34,671,335 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii pancreatic ductal cell granulocyte mucosa of transverse colon apex of heart gastric mucosa muscle layer of sigmoid colon body of stomach upper lobe of left lung monocyte Top expressed in neural layer of retina interventricular septum granulocyte lip right kidney primary visual cortex muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding metal ion binding polyubiquitin modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding Cellular component nucleus cytosol cytoplasm nucleoplasm Biological process negative regulation of endothelial cell apoptotic process regulation of transcription, DNA-templated CD40 signaling pathway protein stabilization positive regulation of macrophage activation transcription, DNA-templated stress-activated MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II apoptotic process toll-like receptor 9 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway protein deubiquitination cellular response to lipopolysaccharide interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79155 231130 Ensembl ENSG00000168884 ENSMUSG00000059866 UniProt Q8NFZ5 Q99JG7 RefSeq (mRNA) NM_024309 NM_001161527 NM_001292016 NM_139064 RefSeq (protein) NP_001154999 NP_001278945 NP_077285 NP_620703 Location (UCSC) Chr 4: 2.74 – 2.76 Mb Chr 5: 34.65 – 34.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.

Further reading

• Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC 2133159. PMID 10385526.
• Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905. S2CID 32414520.
• Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760. S2CID 202644741.
• Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. hdl:2381/866. PMID 12609966.
• Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905. S2CID 31400521.
• Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
• Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
• Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
• Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. Bibcode:2007JRadR..48...13L. doi:10.1269/jrr.0615. PMID 17038805.