TIRAP

TIRAP
Identifiers
Aliases	TIRAP, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein
External IDs	OMIM: 606252; MGI: 2152213; HomoloGene: 14285; GeneCards: TIRAP; OMA:TIRAP - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y92, 3UB2, 3UB3, 3UB4, 4FZ5, 4LQD
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.2 Start 126,283,065 bp End 126,298,845 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A4 Start 35,095,847 bp End 35,111,587 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell monocyte bone marrow cell islet of Langerhans rectum smooth muscle tissue left ovary right ovary right lobe of liver minor salivary glands Top expressed in granulocyte triceps brachii muscle vastus lateralis muscle muscle of thigh conjunctival fornix sternocleidomastoid muscle primitive streak temporal muscle knee joint parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity protein homodimerization activity Toll-like receptor 2 binding Toll-like receptor 4 binding protein binding protein heterodimerization activity phosphatidylinositol-4,5-bisphosphate binding protein kinase C binding identical protein binding Cellular component cytoplasm cytosol membrane plasma membrane endocytic vesicle ruffle membrane Biological process myeloid cell differentiation regulation of innate immune response cellular response to bacterial lipopeptide positive regulation of toll-like receptor 3 signaling pathway positive regulation of interleukin-12 production positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production immune system process positive regulation of JNK cascade MyD88-dependent toll-like receptor signaling pathway positive regulation of interleukin-15 production positive regulation of protein homodimerization activity cell surface receptor signaling pathway response to lipopolysaccharide TIRAP-dependent toll-like receptor 4 signaling pathway cellular response to lipoteichoic acid positive regulation of B cell proliferation regulation of interferon-beta production positive regulation of NF-kappaB transcription factor activity positive regulation of interleukin-8 production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of toll-like receptor 2 signaling pathway 3'-UTR-mediated mRNA stabilization inflammatory response signal transduction defense response to Gram-positive bacterium innate immune response activation of NF-kappaB-inducing kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114609 117149 Ensembl ENSG00000150455 ENSMUSG00000032041 UniProt P58753 Q99JY1 RefSeq (mRNA) NM_001039661 NM_052887 NM_148910 NM_001318776 NM_001318777 NM_001177845 NM_001177846 NM_001177847 NM_054096 RefSeq (protein) NP_001034750 NP_001305705 NP_001305706 NP_683708 NP_001171316 NP_001171317 NP_001171318 NP_473437 Location (UCSC) Chr 11: 126.28 – 126.3 Mb Chr 9: 35.1 – 35.11 Mb PubMed search
Wikidata
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TIRAP (TIR domain containing adaptor protein), also known as MAL (MyD88 adaptor-like protein) is an adapter protein associated with Toll-like receptors (TLRs), specifically TLR2 and TLR4. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. In TLR2 and TLR4, TIRAP is required for the MyD88-dependent pathway of immune signalling. In TLR2 and TLR4 signalling, TIRAP facilitates MyD88 recruitment which allows for downstream activation of NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

See also

• MyD88

External links

• TIRAP+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)