THYN1

THYN1
Identifiers
Aliases	THYN1, MDS012, MY105, THY28, THY28KD, HSPC144, thymocyte nuclear protein 1
External IDs	OMIM: 613739; MGI: 1925112; HomoloGene: 8575; GeneCards: THYN1; OMA:THYN1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EOP, 5J3E
Gene location (Human)
Chr.	Chromosome 11 (human)
End	134,253,370 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	26,918,632 bp
RNA expression pattern
	Top expressed in
	oocyte; ; right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; Brodmann area 9; ; left ovary; ; nucleus accumbens; ; anterior cingulate cortex; ; ganglionic eminence; ; right ovary;
	Top expressed in
	genital tubercle; ; embryo; ; tail of embryo; ; ventricular zone; ; embryo; ; neural layer of retina; ; endocardial cushion; ; Epithelium of choroid plexus; ; spermatocyte; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Orthologs
	29087
	77862
	ENSG00000151500
	ENSMUSG00000035443
	Q9P016
	Q91YJ3
	NM_001037304; NM_001037305; NM_014174; NM_199297; NM_199298
	NM_144543; NM_001326361
	NP_001032381; NP_001032382; NP_054893; NP_954994; NP_954995
	NP_001313290; NP_653126
	Wikidata
View/Edit Human	View/Edit Mouse

Thymocyte nuclear protein 1 is a protein that in humans is encoded by the THYN1 gene.^[5]^[6]^[7]

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151500 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035443 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID 14601557. S2CID 2092518.
↑ Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID 12384300.
1 2 "Entrez Gene: THYN1 thymocyte nuclear protein 1".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jiang X, Toyota H, Takada E, et al. (2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell. 35 (6): 471–8. doi:10.1016/S0040-8166(03)00073-9. PMID 14580360.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Song AX, Chang YG, Gao YG, et al. (2005). "Identification, expression, and purification of a unique stable domain from human HSPC144 protein". Protein Expr. Purif. 42 (1): 146–52. doi:10.1016/j.pep.2005.03.008. PMID 15939300.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151500 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035443 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14601557-5] Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID 14601557. S2CID 2092518.

[pmid12384300-6] Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID 12384300.

[entrez-7] 1 2 "Entrez Gene: THYN1 thymocyte nuclear protein 1".

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THYN1

References

Further reading