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TH10785

From Wikipedia, the free encyclopedia
TH10785
Names
IUPAC name
N-Cyclohexyl-2-cyclopropylquinazolin-4-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C17H21N3/c1-2-6-13(7-3-1)18-17-14-8-4-5-9-15(14)19-16(20-17)12-10-11-12/h4-5,8-9,12-13H,1-3,6-7,10-11H2,(H,18,19,20)
    Key: ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
  • C1CCC(CC1)NC2=NC(=NC3=CC=CC=C32)C4CC4
Properties
C17H21N3
Molar mass 267.376 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

TH10785 is a small molecule that increases OGG1 recruitment and repair of oxidative DNA damage, catalyzing a biochemical reaction not seen in the native protein.[1]

References

[edit]
  1. Michel, Maurice; et al. (2022). "Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function". Science. 376 (6600): 1471–1476. Bibcode:2022Sci...376.1471M. doi:10.1126/science.abf8980. PMID 35737787.