TH10785
Appearance
| Names | |
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| IUPAC name
N-Cyclohexyl-2-cyclopropylquinazolin-4-amine | |
| Identifiers | |
3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
PubChem CID |
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| Properties | |
| C17H21N3 | |
| Molar mass | 267.376 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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TH10785 is a small molecule that increases OGG1 recruitment and repair of oxidative DNA damage, catalyzing a biochemical reaction not seen in the native protein.[1]
References
[edit]- ↑ Michel, Maurice; et al. (2022). "Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function". Science. 376 (6600): 1471–1476. Bibcode:2022Sci...376.1471M. doi:10.1126/science.abf8980. PMID 35737787.
