TESK1

TESK1
Identifiers
Aliases	TESK1, testis-specific kinase 1, testis associated actin remodelling kinase 1
External IDs	OMIM: 601782; MGI: 1201675; HomoloGene: 4577; GeneCards: TESK1; OMA:TESK1 - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.12.1 ↗ ↗ ↗ ↗
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 43,441,939 bp End 43,448,064 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left coronary artery right coronary artery ascending aorta anterior pituitary gastrocnemius muscle gastric mucosa canal of the cervix left lobe of thyroid gland body of stomach subcutaneous adipose tissue Top expressed in seminiferous tubule spermatid spermatocyte superior frontal gyrus muscle of thigh primary visual cortex dentate gyrus of hippocampal formation granule cell internal carotid artery right kidney entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein kinase activity protein binding ATP binding metal ion binding kinase activity protein serine/threonine kinase activity signal transducer activity protein C-terminus binding protein kinase binding Cellular component cytosol cytoplasm nucleus cytoplasmic vesicle Biological process peptidyl-tyrosine phosphorylation spermatogenesis phosphorylation intracellular signal transduction protein phosphorylation actin cytoskeleton organization negative regulation of protein autophosphorylation regulation of protein localization positive regulation of stress fiber assembly negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7016 21754 Ensembl n/a ENSMUSG00000028458 UniProt Q15569 O70146 RefSeq (mRNA) NM_006285 NM_001318230 NM_011571 RefSeq (protein) NP_001305159 NP_006276 NP_035701 Location (UCSC) n/a Chr 4: 43.44 – 43.45 Mb PubMed search
Wikidata
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Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.

Interactions

TESK1 has been shown to interact with YWHAB and SPRY4.

Further reading

• Toshima J, Tanaka T, Mizuno K (1999). "Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop". J. Biol. Chem. 274 (17): 12171–6. doi:10.1074/jbc.274.17.12171. PMID 10207045.
• Røsok O, Pedeutour F, Ree AH, Aasheim HC (1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
• Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K (2001). "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation". Mol. Biol. Cell. 12 (4): 1131–45. doi:10.1091/mbc.12.4.1131. PMC 32292. PMID 11294912.
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.
• Toshima JY, Toshima J, Watanabe T, Mizuno K (2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
• LaLonde DP, Brown MC, Bouverat BP, Turner CE (2005). "Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin". J. Biol. Chem. 280 (22): 21680–8. doi:10.1074/jbc.M500752200. PMID 15817463.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.