TAP1

TAP1
Identifiers
Aliases	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs	OMIM: 170260; MGI: 98483; HomoloGene: 495; GeneCards: TAP1; OMA:TAP1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JJ7
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 7.4.2.14 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,845,209 bp End 32,853,816 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 17.98 cM Start 34,406,527 bp End 34,416,199 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix lymph node blood spleen monocyte duodenum skin of abdomen skin of leg upper lobe of left lung Top expressed in mesenteric lymph nodes granulocyte thymus spleen mucous cell of stomach intestinal villus jejunum Ileal epithelium duodenum subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC protein binding nucleotide binding protein homodimerization activity ABC-type peptide transporter activity TAP2 binding MHC class Ib protein binding ATPase activity protein binding MHC class I protein binding TAP1 binding ATP binding peptide antigen binding ADP binding ATPase-coupled transmembrane transporter activity ABC-type peptide antigen transporter activity peptide transmembrane transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane TAP complex integral component of endoplasmic reticulum membrane mitochondrion endoplasmic reticulum microtubule organizing center phagocytic vesicle membrane endoplasmic reticulum-Golgi intermediate compartment membrane MHC class I peptide loading complex Biological process defense response adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I protein transport peptide transport viral process cytosol to endoplasmic reticulum transport antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6890 21354 Ensembl ENSG00000226173 ENSG00000168394 ENSG00000224212 ENSG00000230705 ENSG00000206297 ENSG00000227816 ENSG00000224748 ENSG00000232367 ENSMUSG00000037321 UniProt Q03518 P21958 RefSeq (mRNA) NM_001292022 NM_000593 NM_001161730 NM_013683 RefSeq (protein) NP_000584 NP_001278951 NP_001155202 NP_038711 Location (UCSC) Chr 6: 32.85 – 32.85 Mb Chr 17: 34.41 – 34.42 Mb PubMed search
Wikidata
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Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter family, it is also known as ABCB2.

Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

See also

• ATP-binding cassette transporter

Interactions

TAP1 has been shown to interact with:

• HLA-A, and
• Tapasin.

Further reading

• Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. doi:10.1006/scel.1993.1007. PMID 8453065.
• Schölz C, Tampé R (2006). "The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms". J. Bioenerg. Biomembr. 37 (6): 509–515. doi:10.1007/s10863-005-9500-1. PMID 16691491. S2CID 28129678.
• Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–441. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
• Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–3936. Bibcode:1992PNAS...89.3932C. doi:10.1073/pnas.89.9.3932. PMC 525605. PMID 1570316.
• Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature. 348 (6303): 741–744. doi:10.1038/348741a0. PMID 2259383. S2CID 4279033.
• Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R (1991). "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway". Nature. 348 (6303): 744–747. doi:10.1038/348744a0. PMID 2259384. S2CID 31875999.
• Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, Gotch F, Townsend A (1990). "Presentation of viral antigen controlled by a gene in the major histocompatibility complex". Nature. 345 (6274): 449–452. Bibcode:1990Natur.345..449C. doi:10.1038/345449a0. PMID 2342577. S2CID 20178053.
• Szafer F, Oksenberg JR, Steinman L (1994). "New allelic polymorphisms in TAP genes". Immunogenetics. 39 (5): 374. doi:10.1007/BF00189240. PMID 8168860. S2CID 23485390.
• Jackson DG, Capra JD (1994). "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11079–11083. doi:10.1073/pnas.90.23.11079. PMC 47925. PMID 8248212.
• Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–866. doi:10.1002/eji.1830230414. PMID 8458375. S2CID 44733094.
• Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
• Chen HL, Gabrilovich D, Tampé R, Girgis KR, Nadaf S, Carbone DP (1996). "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer". Nat. Genet. 13 (2): 210–213. doi:10.1038/ng0696-210. PMID 8640228. S2CID 20367760.
• Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–3255. doi:10.1002/j.1460-2075.1996.tb00689.x. PMC 451885. PMID 8670825.
• Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–883. doi:10.1016/S0960-9822(02)00611-5. PMID 8805302.
• Nijenhuis M, Hämmerling GJ (1997). "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site". J. Immunol. 157 (12): 5467–5477. doi:10.4049/jimmunol.157.12.5467. PMID 8955196.
• Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ (1997). "Antigen processing and presentation by human trophoblast-derived cell lines". J. Immunol. 158 (8): 3587–3592. doi:10.4049/jimmunol.158.8.3587. PMID 9103419.
• Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K (1997). "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP". Immunity. 6 (5): 613–621. doi:10.1016/S1074-7613(00)80349-0. PMID 9175839.

External links

• TAP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.