Stattic

Stattic
Clinical data
Drug class	STAT3 inhibitor
Identifiers
	IUPAC name 6-nitro-1-benzothiophene 1,1-dioxide;
CAS Number	19983-44-9;
PubChem CID	2779853;
ChemSpider	2060075;
ChEBI	CHEBI:86989;
ChEMBL	ChEMBL1337170;
CompTox Dashboard (EPA)	DTXSID70381575 ;
Chemical and physical data
Formula	C8H5NO4S
Molar mass	211.19 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-];
	InChI InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H; Key:ZRRGOUHITGRLBA-UHFFFAOYSA-N;

Stattic is a drug that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer and autoimmune disorders.^[1]^[2]^[3]

References

↑ Ko HJ, Kim YJ (November 2016). "Signal transducer and activator of transcription proteins: regulators of myeloid-derived suppressor cell-mediated immunosuppression in cancer". Archives of Pharmacal Research. 39 (11): 1597–1608. doi:10.1007/s12272-016-0822-9. PMID 27572156.
↑ Samad MA, Ahmad I, Hasan A, Alhashmi MH, Ayub A, Al-Abbasi FA, et al. (April 2025). "STAT3 Signaling Pathway in Health and Disease". MedComm. 6 (4) e70152. doi:10.1002/mco2.70152. PMC 11955304. PMID 40166646.
↑ Wu Z, Lian G, He L, Hu P, Guo Y, Su Z (January 2026). "Targeting JAK-STAT signaling for autoimmune diseases: current understanding, clinical advances, and emerging directions". Immunology and Cell Biology imcb.70078. doi:10.1111/imcb.70078. PMID 41517955.