SPRY3

SPRY3
Identifiers
Aliases	SPRY3, Hspry-3, Gm1409, Gm391, sprouty3, Spry3, sprouty RTK signaling antagonist 3
External IDs	OMIM: 300531; MGI: 1345188; HomoloGene: 4265; GeneCards: SPRY3; OMA:SPRY3 - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cell prefrontal cortex gastrocnemius muscle stromal cell of endometrium left adrenal gland smooth muscle tissue deltoid muscle monocyte ascending aorta n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component cytoplasm membrane cytosol Biological process regulation of signal transduction axon development multicellular organism development negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of MAP kinase activity negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10251 236576 Ensembl n/a ENSMUSG00000061654 UniProt O43610 Q3UUD2 RefSeq (mRNA) NM_001304990 NM_005840 NM_001394353 NM_001394354 NM_001394355 NM_001030293 RefSeq (protein) NP_001291919 NP_005831 NP_001025464 NP_001388778 NP_001388779 NP_001388780 Location (UCSC) n/a n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.

The SPRY3 gene is one of the genes found in the pseudoautosomal regions of the human sex chromosomes (i.e. those 19 genes that are found on both the X and Y chromosome). It is located in the PAR2 region.

Further reading

• Ciccodicola A, D'Esposito M, Esposito T, et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
• Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
• Lim J, Yusoff P, Wong ES, et al. (2002). "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes". Mol. Cell. Biol. 22 (22): 7953–66. doi:10.1128/MCB.22.22.7953-7966.2002. PMC 134720. PMID 12391162.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
• De Bonis ML, Cerase A, Matarazzo MR, et al. (2006). "Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications". Hum. Mol. Genet. 15 (7): 1123–32. doi:10.1093/hmg/ddl027. PMID 16500999.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.

External links

• SPRY3 human gene location in the UCSC Genome Browser.
• SPRY3 human gene details in the UCSC Genome Browser.