SMPD2

SMPD2
Identifiers
Aliases	SMPD2, ISC1, NSMASE, NSMASE1, sphingomyelin phosphodiesterase 2
External IDs	OMIM: 603498; MGI: 1278330; GeneCards: SMPD2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,443,919 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	41,366,365 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left testis; ; right testis; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; sperm; ; gingival epithelium; ; bronchial epithelial cell; ; granulocyte; ; skin of abdomen;
	Top expressed in
	right kidney; ; proximal tubule; ; yolk sac; ; human kidney; ; saccule; ; jejunum; ; retinal pigment epithelium; ; granulocyte; ; duodenum; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingomyelin phosphodiesterase activity; metal ion binding; hydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; caveola;
Biological process	positive regulation of ceramide biosynthetic process; intracellular signal transduction; lipid metabolism; ceramide biosynthetic process; response to mechanical stimulus; sphingomyelin metabolic process; sphingolipid metabolic process; sphingomyelin catabolic process; glycosphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6610
	20598
	ENSG00000135587
	ENSMUSG00000019822
	O60906
	O70572
	NM_003080
	NM_009213
	NP_003071
	NP_033239
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135587 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019822 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W (March 1998). "Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3638–43. Bibcode:1998PNAS...95.3638T. doi:10.1073/pnas.95.7.3638. PMC 19888. PMID 9520418.
↑ "Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)".

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sawai H, Domae N, Nagan N, Hannun YA (December 1999). "Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C". The Journal of Biological Chemistry. 274 (53): 38131–9. doi:10.1074/jbc.274.53.38131. PMID 10608884.
Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA (June 2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". The Journal of Biological Chemistry. 279 (24): 25101–11. doi:10.1074/jbc.M313662200. PMID 15051724.
Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S, Proksch E (June 2004). "Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis". The Journal of Investigative Dermatology. 122 (6): 1423–31. doi:10.1111/j.0022-202X.2004.22621.x. PMID 15175033.
Jana A, Pahan K (October 2004). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". The Journal of Neuroscience. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kim HT, Lee JY, Han BG, Kimm K, Oh B, Shin HD, Namkung JH, Kim E, Park T, Yang JM (May 2007). "Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans". Journal of Dermatological Science. 46 (2): 143–6. doi:10.1016/j.jdermsci.2006.12.001. PMID 17212982.
Tani M, Hannun YA (March 2007). "Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization". The Journal of Biological Chemistry. 282 (13): 10047–56. doi:10.1074/jbc.M611249200. PMID 17272284.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135587 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019822 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9520418-5] Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W (March 1998). "Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3638–43. Bibcode:1998PNAS...95.3638T. doi:10.1073/pnas.95.7.3638. PMC 19888. PMID 9520418.

[entrez-6] "Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)".

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SMPD2

References

Further reading