SCN4B

SCN4B
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; HomoloGene: 18384; GeneCards: SCN4B; OMA:SCN4B - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MZ2, 4MZ3
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,133,377 bp End 118,152,888 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 45,049,693 bp End 45,065,450 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus spinal ganglia putamen right hemisphere of cerebellum pons caudate nucleus lateral nuclear group of thalamus primary visual cortex Brodmann area 23 trigeminal ganglion Top expressed in triceps brachii muscle ankle vastus lateralis muscle sternocleidomastoid muscle temporal muscle knee joint digastric muscle extraocular muscle medial head of gastrocnemius muscle muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function sodium channel regulator activity transmembrane transporter binding sodium channel activity voltage-gated ion channel activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity Cellular component voltage-gated sodium channel complex integral component of membrane membrane intercalated disc intrinsic component of plasma membrane plasma membrane Biological process cardiac muscle contraction sodium ion transmembrane transport sodium ion transport regulation of ion transmembrane transport cardiac muscle cell action potential involved in contraction ion transport regulation of sodium ion transmembrane transporter activity positive regulation of sodium ion transport AV node cell action potential regulation of heart rate by cardiac conduction membrane depolarization during cardiac muscle cell action potential regulation of ventricular cardiac muscle cell membrane repolarization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6330 399548 Ensembl ENSG00000177098 ENSMUSG00000046480 UniProt Q8IWT1 Q7M729 RefSeq (mRNA) NM_001142348 NM_001142349 NM_174934 NM_001013390 RefSeq (protein) NP_001135820 NP_001135821 NP_777594 NP_001013408 Location (UCSC) Chr 11: 118.13 – 118.15 Mb Chr 9: 45.05 – 45.07 Mb PubMed search
Wikidata
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Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein is encoded by the SCN4B gene. Mutations in the SCN4B are associated with long QT syndrome.

SCN4B might additionally function as a cell adhesion molecule.

See also

• Sodium channel

Further reading

• Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–456. PMID 1293796.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–7585. doi:10.1523/JNEUROSCI.23-20-07577.2003. PMC 6740763. PMID 12930796.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–1263. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
• Shimizu H (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IWT1 (Human Sodium channel subunit beta-4 (SCN4B)) at the PDBe-KB.