RSF1

RSF1
Identifiers
Aliases	RSF1, HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1
External IDs	OMIM: 608522; MGI: 2682305; HomoloGene: 41142; GeneCards: RSF1; OMA:RSF1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q14.1 Start 77,660,009 bp End 77,820,869 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 97,229,096 bp End 97,341,985 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon internal globus pallidus sural nerve epithelium of colon tendon of biceps brachii cerebellar vermis Brodmann area 23 pars reticulata middle temporal gyrus external globus pallidus Top expressed in hand Rostral migratory stream tail of embryo genital tubercle ventromedial nucleus lateral septal nucleus otolith organ olfactory tubercle utricle maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding ATPase activity protein binding metal ion binding histone acetyltransferase activity Cellular component RSF complex nucleus nucleoplasm histone acetyltransferase complex Biological process positive regulation of transcription, DNA-templated negative regulation of DNA binding chromatin remodeling positive regulation of viral transcription negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated CENP-A containing chromatin assembly transcription, DNA-templated DNA-templated transcription, initiation nucleosome assembly chromatin organization histone acetylation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51773 233532 Ensembl ENSG00000048649 ENSMUSG00000035623 UniProt Q96T23 Q05DG0 n/a RefSeq (mRNA) NM_016578 NM_001081267 RefSeq (protein) NP_057662 NP_057662.3 n/a Location (UCSC) Chr 11: 77.66 – 77.82 Mb Chr 7: 97.23 – 97.34 Mb PubMed search
Wikidata
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Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]

Further reading

• Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". J. Virol. 69 (2): 1107–14. doi:10.1128/JVI.69.2.1107-1114.1995. PMC 188683. PMID 7815490.
• LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
• Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity". Genomics. 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. Bibcode:2005PNAS..10214004S. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.