RBM23

RBM23
Identifiers
Aliases	RBM23, CAPERbeta, RNPC4, PP239, RNA binding motif protein 23
External IDs	HomoloGene: 56796; GeneCards: RBM23; OMA:RBM23 - orthologs
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CQ4, 2DNZ
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 22,893,204 bp End 22,919,182 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right uterine tube left ovary right lobe of thyroid gland islet of Langerhans body of uterus ventricular zone left lobe of thyroid gland right ovary monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding nucleic acid binding mRNA binding U1 snRNP binding Cellular component membrane nucleus cytoplasmic stress granule ribonucleoprotein complex Biological process mRNA processing 3'-UTR-mediated mRNA destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55147 n/a Ensembl ENSG00000100461 n/a UniProt Q86U06 n/a RefSeq (mRNA) NM_001077351 NM_001077352 NM_001308044 NM_018107 NM_001352762 NM_001352763 NM_001352764 NM_001352765 NM_001352766 n/a RefSeq (protein) NP_001070819 NP_001070820 NP_001294973 NP_060577 NP_001339691 NP_001339692 NP_001339693 NP_001339694 NP_001339695 n/a Location (UCSC) Chr 14: 22.89 – 22.92 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.

Function

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (February 2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Molecular Cell. 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• Overview of all the structural information available in the PDB for UniProt: Q86U06 (Probable RNA-binding protein 23) at the PDBe-KB.