RAPGEF6

RAPGEF6
Identifiers
Aliases	RAPGEF6, KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2, Rap guanine nucleotide exchange factor 6
External IDs	OMIM: 610499; MGI: 2384761; HomoloGene: 22968; GeneCards: RAPGEF6; OMA:RAPGEF6 - orthologs
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2D93, 3LNY
Gene location (Human)
Chr.	Chromosome 5 (human)
End	131,635,231 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,590,111 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; pancreatic epithelial cell; ; Achilles tendon; ; sperm; ; Brodmann area 23; ; cerebellar vermis; ; superficial temporal artery; ; subthalamic nucleus; ; mucosa of ileum; ; Brodmann area 46;
	Top expressed in
	lymph node; ; mesenteric lymph nodes; ; trigeminal ganglion; ; Paneth cell; ; spermatocyte; ; blood; ; granulocyte; ; spleen; ; facial motor nucleus; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidic acid binding; GTP-dependent protein binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane; endocytic vesicle; apical plasma membrane; membrane; centrosome;
Biological process	regulation of GTPase activity; small GTPase mediated signal transduction; positive regulation of GTPase activity; Ras protein signal transduction; microvillus assembly; protein localization to plasma membrane; establishment of endothelial intestinal barrier; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51735
	192786
	ENSG00000158987
	ENSMUSG00000037533
	Q8TEU7
	n/a
NM_016340; NM_001164386; NM_001164387; NM_001164388; NM_001164389;
	NM_001164390
	NM_001252494; NM_001252496; NM_001252497; NM_001252498; NM_175258
NP_001157858; NP_001157859; NP_001157860; NP_001157861; NP_001157862;
	NP_057424
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000158987 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037533 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem. 276 (45): 42219–42225. doi:10.1074/jbc.M105760200. PMID 11524421.
↑ Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol. 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID 12095257.
↑ "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–3342. doi:10.1093/hmg/ddl409. PMID 17030554.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Kuiperij HB, de Rooij J, Rehmann H, et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta. 1593 (2–3): 141–149. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000158987 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11524421-5] Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem. 276 (45): 42219–42225. doi:10.1074/jbc.M105760200. PMID 11524421.

[pmid12095257-6] Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol. 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID 12095257.

[entrez-7] "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".

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RAPGEF6

References

Further reading