RAP2A

RAP2A
Identifiers
Aliases	RAP2A, K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family, Rap2a
External IDs	OMIM: 179540; MGI: 97855; HomoloGene: 10875; GeneCards: RAP2A; OMA:RAP2A - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KAO, 2RAP, 3RAP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 13 (human)
End	97,469,128 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	120,744,606 bp
RNA expression pattern
	Top expressed in
	pons; ; buccal mucosa cell; ; internal globus pallidus; ; superior vestibular nucleus; ; subthalamic nucleus; ; parietal lobe; ; middle temporal gyrus; ; Brodmann area 23; ; inferior ganglion of vagus nerve; ; postcentral gyrus;
	Top expressed in
	sciatic nerve; ; Region I of hippocampus proper; ; subiculum; ; left lung lobe; ; ventromedial nucleus; ; barrel cortex; ; anterior amygdaloid area; ; optic nerve; ; nucleus of stria terminalis; ; primary motor cortex;
	More reference expression data
	; ;
	114560/ More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; magnesium ion binding; GTPase activity; GTP binding; GDP binding;
Cellular component	recycling endosome; cytosol; endosome; membrane; plasma membrane; recycling endosome membrane; midbody;
Biological process	actin cytoskeleton reorganization; microvillus assembly; positive regulation of protein phosphorylation; establishment of protein localization; Rap protein signal transduction; regulation of dendrite morphogenesis; regulation of JNK cascade; negative regulation of cell migration; establishment of epithelial cell apical/basal polarity; positive regulation of protein autophosphorylation; protein localization to plasma membrane; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5911,114560; 5911,114560
	76108
	ENSG00000125249
	ENSMUSG00000051615
	P10114; Q78P65
	Q80ZJ1
	NM_021033; NM_053741
	NM_029519
	NP_066361; NP_446193
	NP_083795
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.^[5] RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A,^[6] RASSF5^[7] and RALGDS.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125249 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051615 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
↑ Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
↑ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081. S2CID 240243.
↑ Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry. 266 (7): 4315–21. doi:10.1016/S0021-9258(20)64324-1. PMID 1900290.
Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.
Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal. 289 ( Pt 2) (Pt 2): 349–55. doi:10.1042/bj2890349. PMC 1132174. PMID 8424780.
Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMC 1170190. PMID 9312017.
Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3): 465–73. doi:10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O. PMID 10591105.
de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal. 350 Pt 1 (Pt 1): 19–29. doi:10.1042/0264-6021:3500019. PMC 1221220. PMID 10926822.
Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081. S2CID 240243.
Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546. S2CID 13499744.
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1593 (2–3): 141–9. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000125249 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051615 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".

[pmid9523700-6] Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.

[pmid11857081-7] Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081. S2CID 240243.

[pmid10085114-8] Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

This page was redesigned at the edge.

RAP2A

Interactions

References

Further reading