RAB6C

RAB6C
Identifiers
Aliases	RAB6C, WTH3, member RAS oncogene family
External IDs	OMIM: 612909; HomoloGene: 108091; GeneCards: RAB6C; OMA:RAB6C - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	129,982,738 bp
RNA expression pattern
	Top expressed in
	testicle; ; endometrium; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; hippocampus proper; ; Brodmann area 9; ; corpus callosum; ; putamen; ; gonad;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity;
Cellular component	cytoplasm; centrosome; intracellular anatomical structure; cytoskeleton; nucleus; microtubule organizing center; cytosol; Golgi apparatus;
Biological process	regulation of centrosome duplication; retrograde transport, endosome to Golgi; intra-Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; mitotic cell cycle; small GTPase mediated signal transduction; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84084
	n/a
	ENSG00000222014
	n/a
	Q9H0N0
	n/a
	NM_032144
	n/a
	NP_115520
	n/a
	Wikidata
View/Edit Human

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.^[3]^[4]^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000222014 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
↑ Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.
↑ "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Fitzgerald ML; Reed GL (1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". Biochem. J. 342 ( Pt 2) (2): 353–60. doi:10.1042/0264-6021:3420353. PMC 1220472. PMID 10455022.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Shan J; Yuan L; Budman DR; Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. Biophys. Acta. 1589 (2): 112–23. doi:10.1016/S0167-4889(02)00164-7. PMID 12007787.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tian K, Jurukovski V, Wang XP, et al. (2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Res. 65 (21): 10024–31. doi:10.1158/0008-5472.CAN-05-1944. PMID 16267028.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000222014 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11054569-3] Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.

[pmid17426708-4] Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.

[entrez-5] "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

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[4]

[5]

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RAB6C

References

Further reading