RAB6B

RAB6B
Identifiers
Aliases	RAB6B, member RAS oncogene family
External IDs	OMIM: 615852; MGI: 107283; HomoloGene: 39749; GeneCards: RAB6B; OMA:RAB6B - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9S, 2FE4, 2FFQ
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.6.5.2 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.1 Start 133,824,235 bp End 133,895,882 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 54.88 cM Start 102,988,986 bp End 103,062,475 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus frontal pole Brodmann area 10 middle temporal gyrus pons pars compacta Brodmann area 46 orbitofrontal cortex superior frontal gyrus superior vestibular nucleus Top expressed in substantia nigra trigeminal ganglion medial dorsal nucleus piriform cortex prefrontal cortex primary motor cortex medial geniculate nucleus pontine nuclei lateral geniculate nucleus temporal lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding protein binding GTPase activity Cellular component Golgi membrane membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment cytosol Golgi apparatus presynapse intracellular anatomical structure Biological process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum protein transport intra-Golgi vesicle-mediated transport retrograde transport, endosome to Golgi vesicle-mediated transport intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51560 270192 Ensembl ENSG00000154917 ENSMUSG00000032549 UniProt Q9NRW1 P61294 RefSeq (mRNA) NM_016577 NM_001363953 NM_173781 RefSeq (protein) NP_057661 NP_001350882 NP_776142 Location (UCSC) Chr 3: 133.82 – 133.9 Mb Chr 9: 102.99 – 103.06 Mb PubMed search
Wikidata
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Ras-related protein Rab-6B is a protein that in humans is encoded by the RAB6B gene.

Further reading

• Chen D, Guo J, Gahl WA (January 1997). "RAB GTPases expressed in human melanoma cells". Biochimica et Biophysica Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
• Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
• Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Garcia-Saez I, Tcherniuk S, Kozielski F (July 2006). "The structure of human neuronal Rab6B in the active and inactive form". Acta Crystallographica Section D. 62 (Pt 7): 725–33. doi:10.1107/S0907444906015319. PMID 16790928.
• Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (October 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.