QPCT

QPCT
Identifiers
Aliases	QPCT, GCT, QC, sQC, glutaminyl-peptide cyclotransferase
External IDs	OMIM: 607065; MGI: 1917786; GeneCards: QPCT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZEE, 2ZEF, 2AFU, 2AFM, 2AFX, 4YU9, 2ZEL, 2ZEG, 2ZEM, 4YWY, 2AFZ, 3PBB, 2ZEH, 2AFS, 3SI0, 2ZEP, 3PBE, 2ZEO, 2ZED, 2AFO, 2ZEN, 2AFW
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.5 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 2 (human) Band 2p22.2 Start 37,342,827 bp End 37,373,322 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E3 Start 79,359,335 bp End 79,397,807 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex beta cell left adrenal gland left adrenal cortex blood bone marrow cell monocyte skin of arm trabecular bone corpus epididymis Top expressed in spermatocyte lens lumbar subsegment of spinal cord iris neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus spermatid seminiferous tubule median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity zinc ion binding glutaminyl-peptide cyclotransferase activity acyltransferase activity metal ion binding Cellular component extracellular exosome extracellular region specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 25797 70536 Ensembl ENSG00000115828 ENSMUSG00000024084 UniProt Q16769 Q9CYK2 RefSeq (mRNA) NM_012413 NM_027455 NM_001316729 RefSeq (protein) NP_036545 NP_001303658 NP_081731 Location (UCSC) Chr 2: 37.34 – 37.37 Mb Chr 17: 79.36 – 79.4 Mb PubMed search
Wikidata
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Glutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Further reading

• Busby WH, Quackenbush GE, Humm J, et al. (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes". J. Biol. Chem. 262 (18): 8532–6. doi:10.1016/S0021-9258(18)47446-7. PMID 3597387.
• Bateman RC, Temple JS, Misquitta SA, Booth RE (2001). "Evidence for essential histidines in human pituitary glutaminyl cyclase". Biochemistry. 40 (37): 11246–50. doi:10.1021/bi011177o. PMID 11551224.
• Schilling S, Hoffmann T, Rosche F, et al. (2002). "Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity". Biochemistry. 41 (35): 10849–57. doi:10.1021/bi0260381. PMID 12196024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Schilling S, Niestroj AJ, Rahfeld JU, et al. (2004). "Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators". J. Biol. Chem. 278 (50): 49773–9. doi:10.1074/jbc.M309077200. PMID 14522962.
• Booth RE, Misquitta SA, Bateman RC (2004). "Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification". Protein Expr. Purif. 32 (1): 141–6. doi:10.1016/S1046-5928(03)00226-2. PMID 14680951.
• Ezura Y, Kajita M, Ishida R, et al. (2005). "Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women". J. Bone Miner. Res. 19 (8): 1296–301. doi:10.1359/JBMR.040324. PMID 15231017. S2CID 8470506.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Huang KF, Liu YL, Cheng WJ, et al. (2005). "Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13117–22. Bibcode:2005PNAS..10213117H. doi:10.1073/pnas.0504184102. PMC 1201592. PMID 16135565.
• Huang QY, Kung AW (2007). "The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population". Journal of Human Genetics. 52 (9): 757–62. doi:10.1007/s10038-007-0178-6. PMID 17687619.