Propanediol dehydratase

propanediol dehydratase
Identifiers
EC no.	4.2.1.28
CAS no.	9026-90-8
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme propanediol dehydratase (EC 4.2.1.28) catalyzes the chemical reaction

propane-1,2-diol $\rightleftharpoons$ propanal + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B₁₂-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1DIO​, PDB: 1EEX​, PDB: 1EGM​, PDB: 1EGV​, PDB: 1IWB​, PDB: 1UC4​, and PDB: 1UC5​.

References

• ABELES RH, LEE HA (1961). "An intramolecular oxidation-reduction requiring a cobamide coenzyme". J. Biol. Chem. 236 (8): 2347–50. doi:10.1016/S0021-9258(18)64083-9. PMID 13680987.
• Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9. doi:10.1128/JB.149.2.413-419.1982. PMC 216523. PMID 7035429.
• LEE HA, ABELES RH (1963). "Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme". J. Biol. Chem. 238 (7): 2367–73. doi:10.1016/S0021-9258(19)67979-2. PMID 13929077.