PhTx-1
PhTx-1 is a toxic fraction isolated from the venom of the Brazilian wandering spider Phoneutria nigriventer.
Composition and Target
[edit]PhTx-1 has as its main toxin PnTx-1, with a molecular mass of 8,594.6 Da, composed of 77 aminoacid residues, 14 of which are cysteines.[1] PnTx-1, also known as Tx1, exerts an inhibitory effect on neuronal sodium channels (Nav1.2).[2] This component is considered highly pathogenic for primates.
References
[edit]- ↑ Resende, Rodrigo R. (2015-01-01). Biotecnologia aplicada à saúde - vol. 1: fundamentos e aplicações (in European Portuguese). Editora Blucher. ISBN 978-85-212-0897-6.
- ↑ Weiss, Marcelo Barros; Paiva, Jorge Wilson Souza (2018-10-10). Acidentes com Animais Peçonhentos (in Brazilian Portuguese). Thieme Revinter Publicações LTDA. ISBN 978-85-5465-084-1.